Durban International offers nonstop service to 24 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Manzini | SHO | Eswatini | 365 km | 0h 45m | RN |
| Maputo | MPM | Mozambique | 433 km | 1h 10m | QR |
| Nelspruit | MQP | South Africa | 468 km | 1h 5m | 4Z |
| Bloemfontein | BFN | South Africa | 471 km | 1h 20m | 5Z |
| Johannesburg | JNB | South Africa | 477 km | 1h 10m | 4Z, 5Z, FA, GE, SA, TK |
| East London | ELS | South Africa | 491 km | 1h 15m | FA |
| Lanseria | HLA | South Africa | 514 km | 1h 15m | FA |
| Port Elizabeth | PLZ | South Africa | 711 km | 1h 25m | 4Z, 5Z, FA |
| George | GRJ | South Africa | 958 km | 2h 5m | 5Z |
| Cape Town | CPT | South Africa | 1,279 km | 2h 10m | 5Z, FA, GE, RN |
| Harare | HRE | Zimbabwe | 1,295 km | 2h 5m | 4Z |
| Dubai | DXB | United Arab Emirates | 6,601 km | 8h 20m | EK |