Xoxocotlan International offers nonstop service to 26 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mexico City | MEX | Mexico | 366 km | 1h 19m | AM, VB, Y4 |
| Mexico City | NLU | Mexico | 389 km | 1h 12m | AM, VB |
| Tuxtla Gutierrez | TGZ | Mexico | 397 km | 1h 6m | VB |
| Queretaro | QRO | Mexico | 542 km | 1h 6m | Y4 |
| Guadalajara | GDL | Mexico | 796 km | 1h 36m | Y4 |
| Merida | MID | Mexico | 861 km | 1h 35m | Y4 |
| Monterrey | MTY | Mexico | 1,033 km | 2h 1m | VB |
| Cancun | CUN | Mexico | 1,128 km | 2h 10m | Y4 |
| Houston | IAH | USA | 1,444 km | 2h 40m | UA |
| Dallas | DFW | USA | 1,761 km | 3h 8m | AA |
| Phoenix | PHX | USA | 2,378 km | 4h 1m | AA |
| Tijuana | TIJ | Mexico | 2,666 km | 3h 59m | VB, Y4 |
| Los Angeles | LAX | USA | 2,865 km | 4h 15m | Y4 |