Ixtapa Zihuatanejo International offers nonstop service to 31 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mexico City | MEX | Mexico | 323 km | 1h 12m | AM, Y4 |
| Mexico City | NLU | Mexico | 351 km | 1h 8m | VB, XN |
| Queretaro | QRO | Mexico | 359 km | 1h 1m | Y4 |
| Guadalajara | GDL | Mexico | 376 km | 1h 3m | Y4 |
| Houston | IAH | USA | 1,505 km | 2h 38m | UA |
| Dallas | DFW | USA | 1,751 km | 3h 1m | AA |
| Phoenix | PHX | USA | 2,045 km | 3h 20m | AA |
| Tijuana | TIJ | Mexico | 2,271 km | 3h 22m | Y4 |
| Los Angeles | LAX | USA | 2,475 km | 3h 47m | AS |
| Chicago | ORD | USA | 2,993 km | 4h 25m | UA |
| San Francisco | SFO | USA | 3,015 km | 4h 36m | AS |
| Minneapolis | MSP | USA | 3,120 km | 4h 19m | SY |
| Calgary | YYC | Canada | 3,881 km | 5h 35m | WS |
| Vancouver | YVR | Canada | 4,012 km | 5h 53m | AC, WS |
| Montreal | YUL | Canada | 4,016 km | 5h 13m | AC |