General Juan N Alvarez International offers nonstop service to 9 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mexico City | MEX | Mexico | 304 km | 1h 13m | AM, Y4, VB |
| Mexico City | NLU | Mexico | 340 km | 1h 10m | VB |
| Queretaro | QRO | Mexico | 429 km | 1h 12m | Y4 |
| Guadalajara | GDL | Mexico | 560 km | 1h 17m | Y4 |
| Monterrey | MTY | Mexico | 998 km | 1h 55m | VB |
| Houston | IAH | USA | 1,531 km | 2h 39m | UA |
| Dallas | DFW | USA | 1,808 km | 3h 18m | AA |
| Tijuana | TIJ | Mexico | 2,461 km | 3h 31m | Y4 |
| Montreal | YUL | Canada | 3,996 km | 5h 10m | TS |