General Juan N Alvarez International offers nonstop service to 22 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Puebla | PBC | Mexico | 300 km | 0h 56m | Y4 |
| Mexico City | MEX | Mexico | 304 km | 1h 14m | AM, Y4 |
| Mexico City | NLU | Mexico | 340 km | 1h 9m | VB, XN |
| Queretaro | QRO | Mexico | 429 km | 1h 10m | Y4, YQ |
| Guadalajara | GDL | Mexico | 560 km | 1h 18m | Y4 |
| Monterrey | MTY | Mexico | 998 km | 1h 54m | VB |
| Cancun | CUN | Mexico | 1,436 km | 2h 31m | VB |
| Houston | IAH | USA | 1,531 km | 2h 42m | UA |
| Dallas | DFW | USA | 1,808 km | 3h 3m | AA |
| Tijuana | TIJ | Mexico | 2,461 km | 3h 31m | Y4 |
| Montreal | YUL | Canada | 3,996 km | 5h 10m | TS |