Palm Beach International offers nonstop service to 44 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Orlando | MCO | USA | 227 km | 1h 0m | WN |
| Marsh Harbour | MHH | Bahamas | 301 km | 1h 0m | UP |
| Charleston | CHS | USA | 687 km | 1h 41m | MX |
| Atlanta | ATL | USA | 877 km | 1h 57m | DL, F9 |
| Charlotte | CLT | USA | 949 km | 2h 5m | AA |
| Asheville | AVL | USA | 997 km | 1h 54m | G4 |
| Raleigh/Durham | RDU | USA | 1,026 km | 2h 8m | MX |
| Norfolk | ORF | USA | 1,190 km | 2h 15m | MX |
| Nashville | BNA | USA | 1,219 km | 2h 20m | WN |
| Richmond | RIC | USA | 1,228 km | 2h 13m | MX |
| Washington | DCA | USA | 1,379 km | 2h 26m | AA, B6 |
| Louisville | SDF | USA | 1,379 km | 2h 50m | AA |
| Dulles | IAD | USA | 1,382 km | 2h 31m | UA |
| Baltimore | BWI | USA | 1,422 km | 2h 25m | WN |
| Cincinnati | CVG | USA | 1,436 km | 2h 37m | G4, F9 |
| Columbus | CMH | USA | 1,499 km | 2h 40m | MX |
| Wilmington | ILG | USA | 1,500 km | 2h 38m | XP |
| Atlantic City | ACY | USA | 1,506 km | 2h 23m | NK |
| Philadelphia | PHL | USA | 1,530 km | 2h 46m | AA, F9 |
| Pittsburgh | PIT | USA | 1,532 km | 2h 32m | G4 |
| Houston | IAH | USA | 1,537 km | 3h 0m | UA |
| Akron | CAK | USA | 1,583 km | 2h 46m | MX |
| Trenton | TTN | USA | 1,584 km | 2h 44m | F9 |
| Cleveland | CLE | USA | 1,641 km | 2h 58m | F9 |
| New York | EWR | USA | 1,646 km | 2h 59m | B6, UA, NK |
| Saint Louis | STL | USA | 1,646 km | 2h 55m | WN |
| New York | JFK | USA | 1,653 km | 2h 48m | B6, DL |
| New York | LGA | USA | 1,664 km | 2h 50m | AA, B6, DL |
| Islip | ISP | USA | 1,692 km | 2h 43m | F9, WN, B6 |
| Westchester County | HPN | USA | 1,700 km | 2h 50m | B6 |
| Detroit | DTW | USA | 1,747 km | 3h 0m | DL |
| New Haven | HVN | USA | 1,747 km | 2h 53m | XP, MX |
| Dallas | DAL | USA | 1,755 km | 3h 15m | WN |
| Dallas | DFW | USA | 1,774 km | 3h 25m | AA |
| Hartford | BDL | USA | 1,821 km | 2h 53m | B6 |
| Chicago | ORD | USA | 1,840 km | 3h 31m | AA, UA |
| Providence | PVD | USA | 1,847 km | 2h 53m | B6 |
| Grand Rapids | GRR | USA | 1,863 km | 2h 57m | G4 |
| Toronto | YYZ | Canada | 1,886 km | 3h 14m | AC, PD |
| Boston | BOS | USA | 1,926 km | 3h 10m | B6, DL, AA |
| Montreal | YUL | Canada | 2,158 km | 3h 30m | AC |
| Minneapolis | MSP | USA | 2,334 km | 4h 2m | DL |
| Denver | DEN | USA | 2,701 km | 4h 34m | UA |
| Los Angeles | LAX | USA | 3,749 km | 5h 47m | B6 |