General Manuel Marquez De Leon International offers nonstop service to 20 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Los Mochis | LMM | Mexico | 220 km | 1h 0m | YQ |
| Culiacan | CUL | Mexico | 303 km | 0h 51m | VB |
| Mazatlan | MZT | Mexico | 430 km | 1h 0m | YQ |
| Hermosillo | HMO | Mexico | 559 km | 1h 10m | YQ |
| Guadalajara | GDL | Mexico | 826 km | 1h 38m | VB, Y4 |
| Monterrey | MTY | Mexico | 1,052 km | 1h 52m | VB |
| Tijuana | TIJ | Mexico | 1,139 km | 1h 56m | VB, Y4 |
| Mexico City | NLU | Mexico | 1,266 km | 2h 9m | VB, Y4 |
| Mexico City | MEX | Mexico | 1,275 km | 2h 17m | AM, Y4 |
| Los Angeles | LAX | USA | 1,344 km | 2h 36m | AS |