Gen Fierro Villalobos Airport offers nonstop service to 28 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Torreon | TRC | Mexico | 431 km | 1h 5m | YQ |
| Los Mochis | LMM | Mexico | 454 km | 1h 5m | YQ |
| Culiacan | CUL | Mexico | 461 km | 1h 5m | YQ |
| Hermosillo | HMO | Mexico | 497 km | 1h 5m | YQ |
| Mazatlan | MZT | Mexico | 614 km | 1h 20m | VB |
| Monterrey | MTY | Mexico | 664 km | 1h 26m | VB |
| Cabo San Lucas | CSW | Mexico | 751 km | 1h 30m | SEN |
| Guadalajara | GDL | Mexico | 945 km | 1h 45m | VB, Y4 |
| Dallas | DFW | USA | 972 km | 1h 59m | AA |
| Tijuana | TIJ | Mexico | 1,137 km | 1h 59m | Y4 |
| Mexico City | NLU | Mexico | 1,216 km | 2h 2m | VB, XN |
| Denver | DEN | USA | 1,242 km | 2h 12m | Y4 |
| Mexico City | MEX | Mexico | 1,242 km | 2h 20m | AM, VB, Y4 |
| Cancun | CUN | Mexico | 2,104 km | 3h 3m | VB |