NW Arkansas Regional offers nonstop service to 29 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Dallas | DFW | USA | 451 km | 1h 29m | AA |
| Nashville | BNA | USA | 686 km | 1h 23m | G4 |
| Houston | IAH | USA | 704 km | 1h 51m | UA |
| Austin | AUS | USA | 743 km | 1h 50m | AA |
| New Orleans | MSY | USA | 792 km | 1h 36m | MX |
| Chicago | ORD | USA | 839 km | 1h 59m | AA, UA |
| Gulf Shores | GUF | USA | 905 km | 1h 42m | G4 |
| Pensacola | PNS | USA | 921 km | 1h 44m | MX |
| Atlanta | ATL | USA | 945 km | 1h 51m | DL |
| Minneapolis | MSP | USA | 960 km | 1h 57m | DL |
| Fort Walton Beach | VPS | USA | 963 km | 1h 45m | G4 |
| Denver | DEN | USA | 992 km | 2h 15m | UA, F9 |
| Detroit | DTW | USA | 1,149 km | 2h 13m | DL |
| Charlotte | CLT | USA | 1,213 km | 2h 20m | AA |
| Saint Petersburg | PIE | USA | 1,433 km | 2h 13m | G4 |
| Tampa | TPA | USA | 1,439 km | 2h 20m | MX |
| Orlando | SFB | USA | 1,479 km | 2h 17m | G4 |
| Orlando | MCO | USA | 1,498 km | 2h 32m | MX |
| Washington | DCA | USA | 1,548 km | 2h 36m | AA |
| Salt Lake City | SLC | USA | 1,617 km | 3h 1m | DL, AA |
| Mesa | AZA | USA | 1,620 km | 3h 0m | G4 |
| Phoenix | PHX | USA | 1,646 km | 3h 3m | AA |
| Philadelphia | PHL | USA | 1,715 km | 2h 49m | AA |
| Fort Lauderdale | FLL | USA | 1,757 km | 2h 42m | G4 |
| Miami | MIA | USA | 1,768 km | 2h 52m | AA |
| New York | LGA | USA | 1,845 km | 3h 3m | AA, DL |
| Las Vegas | LAS | USA | 1,872 km | 3h 5m | G4 |
| Los Angeles | LAX | USA | 2,207 km | 3h 46m | AA, UA |
| San Francisco | SFO | USA | 2,497 km | 4h 9m | UA |