Vanguardia offers nonstop service to 14 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bogota | BOG | Colombia | 83 km | 1h 0m | 9R, AV, VE |
| La Macarena | LMC | Colombia | 220 km | 0h 50m | 9R |
| Cali | CLO | Colombia | 315 km | 1h 15m | VE |
| Medellin | EOH | Colombia | 315 km | 1h 15m | VE |
| Mitu | MVP | Colombia | 519 km | 1h 30m | 9R |
| Puerto Inirida | PDA | Colombia | 637 km | 1h 52m | 9R |
| Puerto Carreno | PCR | Colombia | 699 km | 1h 52m | 9R |