Vanguardia offers nonstop service to 6 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bogota | BOG | Colombia | 83 km | 1h 0m | AV, VE |
| Medellin | EOH | Colombia | 315 km | 1h 15m | VE |
| Cali | CLO | Colombia | 315 km | 1h 15m | VE |
| Mitu | MVP | Colombia | 519 km | 1h 29m | 9R |
| Puerto Inirida | PDA | Colombia | 637 km | 1h 55m | 9R |
| Puerto Carreno | PCR | Colombia | 699 km | 1h 53m | 9R |