Perth International offers nonstop service to 99 destinations, served by 28 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Geraldton | GET | Australia | 368 km | 1h 0m | GD, QF |
| Albany | ALH | Australia | 375 km | 1h 10m | ZL |
| Mount Magnet | MMG | Australia | 460 km | 1h 20m | HK |
| Kalgoorlie | KGI | Australia | 538 km | 1h 5m | GD, QF, QQ, VA |
| Esperance | EPR | Australia | 582 km | 1h 35m | ZL |
| Monkey Mia | MJK | Australia | 709 km | 2h 0m | ZL |
| Wiluna | WUN | Australia | 718 km | 1h 55m | HK |
| Laverton | LVO | Australia | 722 km | 1h 55m | HK |
| Carnarvon | CVQ | Australia | 813 km | 2h 15m | ZL |
| Paraburdoo | PBO | Australia | 986 km | 1h 50m | QF |
| Newman | ZNE | Australia | 1,016 km | 1h 45m | QF, VA |
| Learmonth | LEA | Australia | 1,089 km | 1h 55m | QF |
| Onslow | ONS | Australia | 1,140 km | 2h 0m | VA |
| Karratha | KTA | Australia | 1,246 km | 2h 5m | QF, VA |
| Port Hedland | PHE | Australia | 1,307 km | 2h 10m | QF, VA |
| Broome | BME | Australia | 1,672 km | 2h 35m | QF, VA |
| Alice Springs | ASP | Australia | 1,979 km | 2h 40m | TL |
| Adelaide | ADL | Australia | 2,121 km | 2h 50m | JQ, QF, VA |
| Kununurra | KNX | Australia | 2,206 km | 3h 5m | TL, VA |
| Denpasar | DPS | Indonesia | 2,568 km | 3h 45m | 8B, ID, JQ, OD, QZ |
| Christmas Island | XCH | Christmas Island | 2,599 km | 3h 45m | QF |
| Darwin | DRW | Australia | 2,646 km | 3h 35m | QF, VA |
| Melbourne | MEL | Australia | 2,706 km | 3h 35m | JQ, QF, TL, VA |
| Cocos Islands | CCK | Cocos (Keeling) Islands | 2,935 km | 4h 10m | QF |
| Jakarta | CGK | Indonesia | 3,016 km | 4h 25m | ID |
| Hobart | HBA | Australia | 3,021 km | 4h 10m | QF, VA |
| Canberra | CBR | Australia | 3,091 km | 3h 50m | QF |
| Sydney | SYD | Australia | 3,285 km | 4h 15m | JQ, QF, VA |
| Newcastle | NTL | Australia | 3,361 km | 4h 20m | QF |
| Cairns | CNS | Australia | 3,434 km | 4h 20m | JQ |
| Brisbane | BNE | Australia | 3,613 km | 4h 35m | JQ, QF, VA |
| Coolangatta (Gold Coast) | OOL | Australia | 3,627 km | 4h 25m | JQ |
| Singapore | SIN | Singapore | 3,895 km | 5h 20m | JQ, QF, SQ, TR |
| Kuala Lumpur | KUL | Malaysia | 4,122 km | 5h 45m | AK, MH, OD |
| Phuket | HKT | Thailand | 4,812 km | 6h 28m | JQ |
| Ho Chi Minh City | SGN | Viet Nam | 4,832 km | 6h 30m | VJ, VN |
| Christchurch | CHC | New Zealand | 5,049 km | 6h 5m | JQ, NZ |
| Manila | MNL | Philippines | 5,167 km | 7h 0m | JQ, PR |
| Bangkok | BKK | Thailand | 5,303 km | 7h 0m | JQ, TG |
| Auckland | AKL | New Zealand | 5,348 km | 6h 15m | NZ, QF |
| Mauritius | MRU | Mauritius | 5,894 km | 8h 5m | MK |
| Hong Kong | HKG | Hong Kong SAR | 6,007 km | 7h 50m | CX |
| Guangzhou | CAN | China | 6,128 km | 7h 50m | CZ |
| Tokyo | NRT | Japan | 7,916 km | 9h 38m | NH |
| Johannesburg | JNB | South Africa | 8,324 km | 11h 15m | QF, SA |
| Dubai | DXB | United Arab Emirates | 9,025 km | 10h 55m | EK |
| Doha | DOH | Qatar | 9,313 km | 11h 10m | QR, VA |
| Rome | FCO | Italy | 13,352 km | 16h 40m | QF |
| Paris | CDG | France | 14,261 km | 17h 20m | QF |
| London | LHR | United Kingdom | 14,497 km | 17h 40m | QF |