Chennai International offers nonstop service to 68 destinations, served by 32 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Kadapa | CDP | India | 227 km | 0h 55m | 6E |
| Salem | SXV | India | 263 km | 1h 10m | 6E |
| Bengaluru | BLR | India | 267 km | 1h 5m | 6E, SG, IX |
| Tiruchirappalli | TRZ | India | 292 km | 1h 5m | 6E |
| Jaffna | JAF | Sri Lanka | 353 km | 1h 15m | 6E |
| Mysore | MYQ | India | 389 km | 1h 20m | 6E |
| Vijayawada | VGA | India | 398 km | 1h 25m | 6E |
| Coimbatore | CJB | India | 402 km | 1h 5m | 6E |
| Madurai | IXM | India | 414 km | 1h 25m | 6E, AI |
| Rajahmundry | RJA | India | 490 km | 1h 30m | 6E |
| Shivamogga | RQY | India | 502 km | 1h 20m | SG |
| Kozhikode | CCJ | India | 502 km | 1h 40m | 6E |
| Hyderabad | HYD | India | 505 km | 1h 15m | 6E, SG, 9I |
| Kannur | CNN | India | 515 km | 1h 50m | 6E |
| Kochi | COK | India | 516 km | 1h 15m | 6E, SG |
| Tuticorin | TCR | India | 526 km | 1h 40m | 6E |
| Mangalore | IXE | India | 572 km | 1h 40m | 6E |
| Thiruvananthapuram | TRV | India | 611 km | 1h 15m | 6E |
| Vishakhapatnam | VTZ | India | 619 km | 1h 15m | 6E |
| Colombo | CMB | Sri Lanka | 643 km | 1h 25m | 6E, UL |
| Goa | GOI | India | 732 km | 1h 30m | 6E |
| Goa | GOX | India | 744 km | 1h 25m | 6E |
| Pune | PNQ | India | 911 km | 1h 40m | 6E, SG, IX |
| Raipur | RPR | India | 923 km | 1h 50m | 6E |
| Shirdi | SAG | India | 965 km | 1h 55m | 6E |
| Bhubaneswar | BBI | India | 1,005 km | 1h 50m | 6E |
| Mumbai | NMI | India | 1,008 km | 1h 50m | 6E |
| Mumbai | BOM | India | 1,032 km | 2h 5m | 6E, AI, SG |
| Indore | IDR | India | 1,172 km | 2h 0m | 6E |
| Surat Gujarat | STV | India | 1,197 km | 2h 10m | 6E |
| Ranchi | IXR | India | 1,267 km | 2h 5m | 6E |
| Vadodara | BDQ | India | 1,269 km | 2h 30m | 6E |
| Ahmedabad | AMD | India | 1,371 km | 2h 25m | 6E, SG |
| Port Blair | IXZ | India | 1,374 km | 2h 15m | 6E, IX |
| Kolkata | CCU | India | 1,383 km | 2h 25m | 6E, SG, IX |
| Andal | RDP | India | 1,394 km | 2h 25m | 6E |
| Varanasi | VNS | India | 1,408 km | 2h 15m | 6E |
| Patna | PAT | India | 1,488 km | 2h 15m | 6E |
| Lucknow | LKO | India | 1,527 km | 2h 25m | 6E |
| Jaipur | JAI | India | 1,598 km | 2h 30m | 6E |
| Dhaka | DAC | Bangladesh | 1,616 km | 2h 43m | 6E, BS, BG |
| Bagdogra | IXB | India | 1,739 km | 2h 55m | 6E |
| Delhi | DEL | India | 1,753 km | 2h 55m | 6E, AI |
| Ghaziabad | HDO | India | 1,765 km | 2h 45m | 6E |
| Yangon | RGN | Myanmar | 1,771 km | 3h 0m | 8M |
| Guwahati | GAU | India | 1,881 km | 2h 50m | 6E, IX |
| Chandigarh | IXC | India | 1,989 km | 2h 45m | 6E |
| Phuket | HKT | Thailand | 2,056 km | 3h 10m | FD |
| Bangkok | DMK | Thailand | 2,215 km | 3h 30m | FD, SL |
| Bangkok | BKK | Thailand | 2,231 km | 3h 35m | TG, 6E |
| Penang | PEN | Malaysia | 2,365 km | 3h 40m | 6E |
| Muscat | MCT | Oman | 2,589 km | 3h 50m | 6E, WY, OV |
| Kuala Lumpur | KUL | Malaysia | 2,629 km | 4h 0m | AK, MH, 6E |
| Sharjah | SHJ | United Arab Emirates | 2,922 km | 4h 20m | G9 |
| Singapore | SIN | Singapore | 2,924 km | 4h 30m | 6E, AI, SQ, TR |
| Dubai | DXB | United Arab Emirates | 2,933 km | 4h 20m | 6E, EK, IX |
| Abu Dhabi | AUH | United Arab Emirates | 2,967 km | 4h 15m | EY, 6E, 3L |
| Doha | DOH | Qatar | 3,286 km | 4h 45m | 6E, QR |
| Bahrain | BAH | Bahrain | 3,417 km | 5h 4m | GF |
| Hong Kong | HKG | Hong Kong SAR | 3,719 km | 5h 20m | CX |
| Kuwait | KWI | Kuwait | 3,778 km | 5h 15m | KU, 6E, J9 |
| Bandar Seri Begawan | BWN | Brunei Darussalam | 3,920 km | 5h 35m | BI |
| Mauritius | MRU | Mauritius | 4,440 km | 5h 45m | MK |
| Addis Ababa | ADD | Ethiopia | 4,538 km | 6h 13m | ET |
| Denpasar | DPS | Indonesia | 4,555 km | 6h 20m | 6E |
| Saint Denis de la Reunion | RUN | Reunion | 4,616 km | 6h 20m | 6E |
| Frankfurt | FRA | Germany | 7,598 km | 10h 35m | LH |
| London | LHR | United Kingdom | 8,241 km | 11h 30m | BA |