Kansai International Airport offers nonstop service to 126 destinations, served by 65 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tokyo | HND | Japan | 432 km | 1h 15m | 7G, JL, NH |
| Fukuoka | FUK | Japan | 453 km | 1h 25m | MM |
| Miyazaki | KMI | Japan | 454 km | 1h 10m | MM |
| Tokyo | NRT | Japan | 491 km | 1h 25m | GK, MM |
| Kagoshima | KOJ | Japan | 513 km | 1h 20m | MM |
| Nagasaki | NGS | Japan | 521 km | 1h 18m | MM |
| Busan | PUS | Republic of Korea | 581 km | 1h 35m | 7C, BX, LJ, TW, ZE |
| Daegu | TAE | Republic of Korea | 623 km | 1h 30m | TW |
| Sendai | SDJ | Japan | 654 km | 1h 23m | MM |
| Cheongju | CJJ | Republic of Korea | 746 km | 1h 40m | TW |
| Jeju | CJU | Republic of Korea | 814 km | 2h 0m | TW |
| Seoul | GMP | Republic of Korea | 835 km | 1h 58m | 7C, KE, MM, OZ |
| Amami O Shima | ASJ | Japan | 848 km | 1h 45m | MM |
| Seoul | ICN | Republic of Korea | 861 km | 1h 55m | 7C, BX, KE, LJ, MM, OZ, RS, TW, WE, ZE |
| Sapporo | CTS | Japan | 1,082 km | 1h 55m | GK, JL, MM, NH |
| Okinawa | OKA | Japan | 1,168 km | 2h 25m | GK, MM, NH, NU |
| Kushiro | KUH | Japan | 1,231 km | 2h 5m | MM |
| Memanbetsu | MMB | Japan | 1,299 km | 2h 10m | MM |
| Shanghai | PVG | China | 1,309 km | 2h 38m | 9C, CA, FM, HO, JL, MM, MU, NH |
| Dalian | DLC | China | 1,321 km | 2h 25m | 9C |
| Qingdao | TAO | China | 1,391 km | 2h 55m | QW, SC |
| Wuxi | WUX | China | 1,421 km | 2h 40m | ZH |
| Miyakojima | MMY | Japan | 1,438 km | 2h 40m | NH, NU |
| Hangzhou | HGH | China | 1,468 km | 3h 0m | CA, GJ, JD |
| Ishigaki | ISG | Japan | 1,540 km | 2h 45m | MM, NH, NU |
| Nanjing | NKG | China | 1,556 km | 2h 50m | HO |
| Jinan | TNA | China | 1,652 km | 3h 3m | SC |
| Tianjin | TSN | China | 1,676 km | 3h 0m | GS |
| Taipei | TPE | Taiwan | 1,703 km | 3h 8m | BR, CI, CX, D7, GK, IT, JL, JX, MM, SL, VZ |
| Beijing | PEK | China | 1,765 km | 3h 35m | CA, HU, NH |
| Kaohsiung | KHH | Taiwan | 1,959 km | 3h 25m | AK, BR, CI, IT, MM |
| Guangzhou | CAN | China | 2,457 km | 4h 15m | AQ, CZ |
| Shenzhen | SZX | China | 2,463 km | 4h 20m | ZH |
| Hong Kong | HKG | Hong Kong SAR | 2,474 km | 4h 20m | CX, HB, HX, MM, UO |
| Guam | GUM | Guam | 2,512 km | 3h 40m | TW, UA |
| Macau | MFM | Macau SAR | 2,515 km | 4h 0m | NX |
| Manila | MNL | Philippines | 2,629 km | 4h 30m | 5J, GK, PR |
| Ulaanbaatar | UBN | Mongolia | 2,780 km | 4h 40m | OM |
| Cebu City | CEB | Philippines | 2,907 km | 4h 45m | 5J, PR |
| Hanoi | HAN | Viet Nam | 3,232 km | 5h 0m | VJ, VN |
| Da Nang | DAD | Viet Nam | 3,381 km | 4h 55m | VJ, VN |
| Ho Chi Minh City | SGN | Viet Nam | 3,906 km | 5h 25m | VJ, VN |
| Chiang Mai | CNX | Thailand | 3,979 km | 5h 55m | VZ |
| Bangkok | DMK | Thailand | 4,156 km | 6h 0m | XJ |
| Bangkok | BKK | Thailand | 4,159 km | 6h 10m | JL, MM, TG, VZ |
| Singapore | SIN | Singapore | 4,893 km | 6h 38m | MM, SQ, TR |
| Kuala Lumpur | KUL | Malaysia | 4,935 km | 7h 10m | D7, MH, OD |
| Cairns | CNS | Australia | 5,786 km | 7h 10m | JQ |
| Honolulu | HNL | USA | 6,624 km | 7h 35m | AS, JL |
| Brisbane | BNE | Australia | 7,098 km | 8h 45m | JQ |
| Dubai | DXB | United Arab Emirates | 7,590 km | 9h 50m | EK |
| Abu Dhabi | AUH | United Arab Emirates | 7,698 km | 10h 15m | EY |
| Sydney | SYD | Australia | 7,748 km | 9h 45m | JQ |
| Helsinki | HEL | Finland | 7,749 km | 13h 5m | AY |
| Doha | DOH | Qatar | 7,919 km | 11h 5m | QR |
| Vancouver | YVR | Canada | 7,952 km | 9h 15m | AC |
| San Francisco | SFO | USA | 8,709 km | 10h 15m | UA |
| Istanbul | IST | Turkiye | 8,765 km | 13h 5m | TK |
| Los Angeles | LAX | USA | 9,240 km | 10h 20m | JL, UA |
| Munich | MUC | Germany | 9,260 km | 14h 18m | LH |
| Amsterdam | AMS | Netherlands | 9,262 km | 14h 20m | KL |
| Paris | CDG | France | 9,647 km | 14h 50m | AF |
| Toronto | YYZ | Canada | 10,662 km | 12h 33m | AC |