Guam offers nonstop service to 16 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Rota | ROP | Northern Mariana Islands | 88 km | 0h 30m | S2 |
| Saipan | SPN | Northern Mariana Islands | 205 km | 0h 45m | UA |
| Yap, Caroline Islands | YAP | Micronesia | 855 km | 1h 35m | UA |
| Truk, Caroline Islands | TKK | Micronesia | 1,019 km | 1h 50m | UA |
| Koror | ROR | Palau | 1,312 km | 2h 10m | UA |
| Pohnpei, Caroline Islands | PNI | Micronesia | 1,634 km | 2h 35m | UA |
| Cebu City | CEB | Philippines | 2,294 km | 3h 33m | PR |
| Tokyo | HND | Japan | 2,495 km | 3h 50m | UA |
| Nagoya | NGO | Japan | 2,499 km | 3h 45m | UA |
| Tokyo | NRT | Japan | 2,507 km | 3h 55m | JL, UA |
| Osaka | KIX | Japan | 2,512 km | 4h 0m | TW, UA |
| Manila | MNL | Philippines | 2,570 km | 3h 55m | PR, UA |
| Taipei | TPE | Taiwan | 2,782 km | 4h 28m | UA |
| Busan | PUS | Republic of Korea | 2,882 km | 4h 30m | BX, LJ |
| Seoul | ICN | Republic of Korea | 3,220 km | 4h 40m | KE, LJ, RS |
| Honolulu | HNL | USA | 6,115 km | 7h 15m | UA |