Mactan–Cebu International offers nonstop service to 44 destinations, served by 26 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bacolod | BCD | Philippines | 117 km | 0h 50m | DG, PR, 5J |
| Dumaguete | DGT | Philippines | 132 km | 0h 55m | DG, 5J |
| Mambajao | CGM | Philippines | 141 km | 0h 55m | DG |
| Tacloban | TAC | Philippines | 152 km | 0h 50m | DG, PR, 5J |
| Iloilo | ILO | Philippines | 172 km | 0h 55m | 5J, DG, PR, Z2 |
| Surigao | SUG | Philippines | 175 km | 0h 55m | DG |
| Cagayan De Oro | CGY | Philippines | 195 km | 0h 55m | DG, PR, 5J |
| Dipolog | DPL | Philippines | 202 km | 1h 5m | DG |
| Calbayog | CYP | Philippines | 204 km | 1h 0m | DG, PR |
| Borongan | BPA | Philippines | 222 km | 1h 0m | PR |
| Butuan | BXU | Philippines | 223 km | 0h 55m | DG, PR, 5J |
| Del Carmin | IAO | Philippines | 228 km | 1h 0m | DG, PR, 2R |
| Masbate | MBT | Philippines | 230 km | 1h 10m | DG |
| Ozamiz | OZC | Philippines | 236 km | 1h 5m | DG, PR |
| Catarman | CRM | Philippines | 252 km | 0h 55m | PR |
| Pagadian | PAG | Philippines | 281 km | 1h 15m | DG |
| Caticlan | MPH | Philippines | 284 km | 1h 5m | 5J, DG, PR, Z2 |
| Daraga | DRP | Philippines | 311 km | 1h 15m | DG |
| Cotabato | CBO | Philippines | 349 km | 1h 8m | PR |
| Davao | DVO | Philippines | 396 km | 1h 10m | 5J, PR, Z2, QR |
| Zamboanga | ZAM | Philippines | 430 km | 1h 10m | 5J, PR |
| Busuanga | USU | Philippines | 461 km | 1h 25m | DG, PR, 2R |
| General Santos City | GES | Philippines | 486 km | 1h 20m | 5J, PR |
| El Nido | ENI | Philippines | 509 km | 1h 48m | T6, DG |
| Manila | MNL | Philippines | 565 km | 1h 28m | 5J, PR, Z2, DG |
| Puerto Princesa | PPS | Philippines | 576 km | 1h 20m | 5J, PR |
| Angeles | CRK | Philippines | 655 km | 1h 25m | 5J, EK, DG |
| Taipei | TPE | Taiwan | 1,659 km | 2h 50m | BR, CI, JX |
| Jinjiang | JJN | China | 1,702 km | 3h 0m | MF |
| Hong Kong | HKG | Hong Kong SAR | 1,706 km | 3h 0m | 5J, CX |
| Macau | MFM | Macau SAR | 1,717 km | 2h 50m | Z2 |
| Ho Chi Minh City | SGN | Viet Nam | 1,896 km | 3h 5m | PR, 5J |
| Hanoi | HAN | Viet Nam | 2,287 km | 3h 50m | VN, Z2 |
| Guam | GUM | Guam | 2,294 km | 3h 45m | PR |
| Shanghai | PVG | China | 2,317 km | 4h 8m | MU |
| Singapore | SIN | Singapore | 2,423 km | 3h 45m | 5J, TR, SQ |
| Bangkok | DMK | Thailand | 2,574 km | 4h 0m | 5J, Z2 |
| Kuala Lumpur | KUL | Malaysia | 2,599 km | 3h 50m | Z2, FY |
| Busan | PUS | Republic of Korea | 2,799 km | 4h 25m | BX, LJ, 7C |
| Osaka | KIX | Japan | 2,907 km | 4h 35m | PR, 5J |
| Nagoya | NGO | Japan | 3,014 km | 4h 15m | PR |
| Seoul | ICN | Republic of Korea | 3,017 km | 4h 30m | 5J, 7C, KE, LJ, OZ, PR, TW |
| Tokyo | NRT | Japan | 3,271 km | 4h 45m | 5J, PR, UA |
| Brisbane | BNE | Australia | 5,223 km | 6h 45m | JQ |