Wuxi Airport offers nonstop service to 58 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Qingdao | TAO | China | 540 km | 1h 20m | HO, MU |
| Jeju | CJU | Republic of Korea | 612 km | 1h 45m | HO |
| Fuzhou | FOC | China | 620 km | 1h 35m | MF |
| Yantai | YNT | China | 685 km | 1h 40m | ZH |
| Jinjiang | JJN | China | 763 km | 1h 50m | ZH |
| Xiangyang | XFN | China | 773 km | 1h 50m | GJ |
| Changsha | CSX | China | 786 km | 2h 0m | MU, HO, DR |
| Xiamen | XMN | China | 802 km | 1h 50m | MU |
| Dalian | DLC | China | 834 km | 1h 45m | MU, GJ, DR, DZ |
| Changzhi | CIH | China | 856 km | 1h 50m | HO |
| Seoul | ICN | Republic of Korea | 861 km | 2h 5m | MU, ZH |
| Shiyan | WDS | China | 906 km | 2h 15m | A6 |
| Beijing | PKX | China | 960 km | 2h 10m | MU |
| Jieyang | SWA | China | 961 km | 2h 15m | MU, 9C |
| Yuncheng | YCU | China | 961 km | 2h 0m | ZH |
| Dayong | DYG | China | 995 km | 1h 55m | A6 |
| Taiyuan | TYN | China | 996 km | 2h 5m | MU, ZH |
| Beijing | PEK | China | 1,013 km | 2h 5m | ZH |
| Yingkou | YKH | China | 1,018 km | 2h 15m | AQ |
| Huizhou | HUZ | China | 1,098 km | 2h 20m | HO, ZH |
| Xian | XIY | China | 1,137 km | 2h 20m | MU, ZH |
| Guangzhou | CAN | China | 1,140 km | 2h 35m | AQ, CZ, MU, ZH |
| Tongren | TEN | China | 1,147 km | 2h 0m | A6 |
| Yan'an | ENY | China | 1,152 km | 2h 20m | A6 |
| Shenyang | SHE | China | 1,158 km | 2h 23m | AQ, MU, ZH, A6 |
| Shenzhen | SZX | China | 1,179 km | 2h 30m | CZ, DZ, MU, ZH, DR |
| Chifeng | CIF | China | 1,191 km | 2h 35m | AQ |
| Hong Kong | HKG | Hong Kong SAR | 1,203 km | 2h 45m | ZH |
| Guilin | KWL | China | 1,231 km | 2h 25m | HO |
| Macau | MFM | Macau SAR | 1,237 km | 2h 40m | ZH, MU |
| Zhuhai | ZUH | China | 1,262 km | 2h 43m | ZH, HO, DZ |
| Zhuhai | ZUH | China | 1,262 km | 2h 43m | ZH, HO, DZ |
| Hohhot | HET | China | 1,294 km | 2h 35m | A6 |
| Dongsheng | DSN | China | 1,304 km | 2h 25m | MU |
| Bazhong | BZX | China | 1,306 km | 2h 45m | A6 |
| Chongqing | CKG | China | 1,335 km | 2h 40m | 3U, MU, ZH, HO |
| Zunyi | ZYI | China | 1,370 km | 2h 40m | A6 |
| Osaka | KIX | Japan | 1,421 km | 2h 20m | ZH |
| Guiyang | KWE | China | 1,435 km | 2h 40m | AQ, ZH, DR, A6 |
| Changchun | CGQ | China | 1,462 km | 2h 35m | A6, HO |
| Luzhou | LZO | China | 1,463 km | 2h 55m | GJ |
| Chengdu | TFU | China | 1,532 km | 3h 0m | HO, MU, A6, DR, ZH |
| Yibin | YBP | China | 1,556 km | 3h 10m | A6 |
| Nanning | NNG | China | 1,562 km | 2h 58m | HO, ZH |
| Chengdu | CTU | China | 1,573 km | 2h 50m | 3U, ZH |
| Harbin | HRB | China | 1,646 km | 3h 5m | HO, A6, MU |
| Lanzhou | LHW | China | 1,646 km | 2h 50m | ZH |
| Xining | XNN | China | 1,784 km | 3h 5m | A6 |
| Sanya | SYX | China | 1,833 km | 3h 15m | HO, MU |
| Kunming | KMG | China | 1,853 km | 3h 20m | MU, A6, DR, 8L |
| Lijiang | LJG | China | 2,032 km | 3h 40m | A6 |
| Jinghong | JHG | China | 2,216 km | 3h 48m | A6, MU |
| Tengchong | TCZ | China | 2,268 km | 4h 0m | A6 |
| Mangshi | LUM | China | 2,287 km | 3h 23m | MU |
| Sihanoukville | KOS | Cambodia | 2,890 km | 4h 30m | DR |
| Shihezi | SHF | China | 3,319 km | 5h 18m | A6 |
| Kuala Lumpur | KUL | Malaysia | 3,738 km | 5h 43m | HO |
| Singapore | SIN | Singapore | 3,756 km | 5h 30m | HO |