Irkutsk offers nonstop service to 92 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Ulan-Ude | UUD | Russia | 221 km | 0h 50m | IO, S7 |
| Bratsk | BTK | Russia | 487 km | 1h 10m | S7 |
| Ust-Kut | UKX | Russia | 517 km | 1h 20m | UT |
| Ulaanbaatar | UBN | Mongolia | 544 km | 0h 55m | IO |
| Chita | HTA | Russia | 612 km | 1h 10m | IO, S7 |
| Ust-Ilimsk | UIK | Russia | 662 km | 1h 48m | IO |
| Taksimo | TKM | Russia | 823 km | 2h 20m | IO |
| Bodaybo | ODO | Russia | 885 km | 2h 35m | IO |
| Krasnojarsk | KJA | Russia | 886 km | 1h 50m | S7, SU |
| Talakan | TLK | Russia | 942 km | 1h 40m | IO, SU |
| Erbogachen | ERG | Russia | 1,026 km | 2h 40m | IO |
| Lensk | ULK | Russia | 1,137 km | 3h 20m | IO |
| Mirnyj | MJZ | Russia | 1,279 km | 1h 50m | S7 |
| Tomsk | TOF | Russia | 1,321 km | 3h 40m | UT |
| Olokminsk | OLZ | Russia | 1,339 km | 3h 35m | IO |
| Neryungri | NER | Russia | 1,418 km | 2h 25m | S7 |
| Novosibirsk | OVB | Russia | 1,460 km | 2h 30m | S7 |
| Blagoveschensk | BQS | Russia | 1,611 km | 2h 45m | IO |
| Beijing | PEK | China | 1,647 km | 2h 55m | CA |
| Beijing | PKX | China | 1,694 km | 3h 0m | S7 |
| Yakutsk | YKS | Russia | 1,865 km | 2h 50m | R3, S7 |
| Omsk | OMS | Russia | 2,058 km | 3h 20m | S7 |
| Khabarovsk | KHV | Russia | 2,212 km | 3h 15m | HZ, IO, S7, SU |
| Vladivostok | VVO | Russia | 2,283 km | 4h 5m | S7, U6 |
| Tyumen | TJM | Russia | 2,534 km | 4h 10m | S7 |
| Osh | OSS | Kyrgyzstan | 2,720 km | 4h 40m | S7 |
| Shanghai | PVG | China | 2,743 km | 4h 20m | S7 |
| Namangan | NMA | Uzbekistan | 2,772 km | 4h 40m | HY, U6 |
| Yuzhno-Sakhalinsk | UUS | Russia | 2,803 km | 3h 58m | S7 |
| Fergana | FEG | Uzbekistan | 2,807 km | 4h 40m | S7 |
| Yekaterinburg | SVX | Russia | 2,814 km | 4h 25m | S7, U6 |
| Tashkent | TAS | Uzbekistan | 2,908 km | 4h 45m | HY, U6 |
| Ufa | UFA | Russia | 3,168 km | 5h 0m | S7 |
| Orenburg | REN | Russia | 3,291 km | 4h 45m | IO |
| Guangzhou | CAN | China | 3,295 km | 5h 0m | S7 |
| Kazan | KZN | Russia | 3,538 km | 5h 10m | N4 |
| Samara | KUF | Russia | 3,562 km | 4h 50m | IO |
| Petropavlovsk-Kamchatsky | PKC | Russia | 3,567 km | 4h 50m | S7 |
| Sanya | SYX | China | 3,794 km | 5h 43m | SU |
| Moscow | DME | Russia | 4,219 km | 6h 23m | S7, U6 |
| Moscow | SVO | Russia | 4,222 km | 6h 18m | SU |
| Bangkok | BKK | Thailand | 4,291 km | 6h 23m | S7, SU |
| Saint Petersburg | LED | Russia | 4,443 km | 6h 35m | S7, SU |
| Nha Trang | CXR | Viet Nam | 4,487 km | 6h 55m | SU |
| Phuket | HKT | Thailand | 4,928 km | 7h 3m | S7, SU |