Orenburg offers nonstop service to 27 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Yekaterinburg | SVX | Russia | 652 km | 1h 35m | WZ |
| Nizhniy Novgorod | GOJ | Russia | 908 km | 1h 30m | RT |
| Makhachkala | MCX | Russia | 1,157 km | 2h 25m | WZ |
| Mineralnye Vody | MRV | Russia | 1,246 km | 3h 0m | A4 |
| Moscow | SVO | Russia | 1,269 km | 2h 20m | 5N, SU |
| Baku | GYD | Azerbaijan | 1,325 km | 2h 30m | IO |
| Sukhumi | SUI | Georgia | 1,464 km | 1h 45m | 7R |
| Adler/Sochi | AER | Russia | 1,484 km | 3h 10m | 5N, EO, IO, N4 |
| Saint Petersburg | LED | Russia | 1,797 km | 2h 55m | 5N, N4, SU |
| Novosibirsk | OVB | Russia | 1,832 km | 2h 45m | S7 |
| Antalya | AYT | Turkiye | 2,547 km | 4h 25m | 2S |
| Sharm el Sheikh | SSH | Egypt | 3,174 km | 5h 25m | SM |
| Irkutsk | IKT | Russia | 3,291 km | 4h 35m | IO |