Orenburg offers nonstop service to 8 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Yekaterinburg | SVX | Russia | 652 km | 1h 35m | WZ |
| Zhukovsky | ZIA | Russia | 1,214 km | 2h 10m | WZ |
| Mineralnye Vody | MRV | Russia | 1,246 km | 3h 0m | A4 |
| Moscow | SVO | Russia | 1,269 km | 2h 20m | SU, N4, 5N |
| Baku | GYD | Azerbaijan | 1,325 km | 2h 30m | IO |
| Adler/Sochi | AER | Russia | 1,484 km | 3h 5m | EO, 5N |
| Saint Petersburg | LED | Russia | 1,797 km | 2h 55m | SU, 5N, N4 |
| Novosibirsk | OVB | Russia | 1,832 km | 2h 45m | S7 |