Osh offers nonstop service to 23 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tashkent | TAS | Uzbekistan | 303 km | 1h 10m | C6 |
| Bishkek | BSZ | Kyrgyzstan | 305 km | 0h 55m | K9, KA |
| Tamchy | IKU | Kyrgyzstan | 394 km | 0h 50m | K9 |
| Karakol | IKG | Kyrgyzstan | 512 km | 1h 20m | |
| Urumqi | URC | China | 1,264 km | 2h 20m | CZ |
| Novosibirsk | OVB | Russia | 1,759 km | 2h 45m | S7, YK |
| Chelyabinsk | CEK | Russia | 1,832 km | 2h 55m | U6 |
| Tyumen | TJM | Russia | 1,919 km | 3h 3m | N4 |
| Yekaterinburg | SVX | Russia | 1,993 km | 3h 5m | U6, YK |
| Samara | KUF | Russia | 2,222 km | 3h 30m | U6 |
| Krasnojarsk | KJA | Russia | 2,247 km | 3h 5m | YK, U6, SU |
| Nizhnevartovsk | NJC | Russia | 2,276 km | 3h 25m | U6 |
| Surgut | SGC | Russia | 2,306 km | 3h 30m | YK, KA |
| Kazan | KZN | Russia | 2,394 km | 3h 50m | U6 |
| Kuwait | KWI | Kuwait | 2,581 km | 4h 20m | J9 |
| Irkutsk | IKT | Russia | 2,720 km | 4h 0m | YK, S7 |
| Zhukovsky | ZIA | Russia | 3,021 km | 4h 40m | U6 |
| Moscow | DME | Russia | 3,031 km | 4h 40m | U6, YK |
| Moscow | VKO | Russia | 3,074 km | 4h 40m | KA |
| Moscow | SVO | Russia | 3,079 km | 4h 40m | SU |
| Saint Petersburg | LED | Russia | 3,613 km | 5h 35m | U6, YK |
| Istanbul | SAW | Turkiye | 3,632 km | 5h 35m | PC |
| Jeddah | JED | Saudi Arabia | 3,797 km | 6h 8m | XY |