Nouakchott International Airport offers nonstop service to 12 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Nouadhibou | NDB | Mauritania | 311 km | 0h 40m | L6 |
| Dakar | DSS | Senegal | 419 km | 1h 8m | L6, HC |
| Banjul | BJL | Gambia | 553 km | 1h 20m | TK |
| Nema | EMN | Mauritania | 941 km | 1h 30m | L6 |
| Conakry | CKY | Guinea | 998 km | 1h 45m | AF, KP |
| Las Palmas | LPA | Spain | 1,067 km | 1h 40m | NT, L6 |
| Bamako | BKO | Mali | 1,070 km | 1h 50m | L6, KP |
| Casablanca | CMN | Morocco | 1,866 km | 2h 45m | AT, L6 |
| Algiers | ALG | Algeria | 2,771 km | 3h 35m | AH |
| Tunis | TUN | Tunisia | 3,282 km | 4h 30m | L6, TU |
| Paris | CDG | France | 3,791 km | 5h 10m | AF |
| Istanbul | IST | Turkiye | 4,941 km | 6h 33m | TK |