Amilcar Cabral International Airport offers nonstop service to 40 destinations, served by 16 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Boa Vista | BVC | Cape Verde | 66 km | 0h 28m | WK, VR, TO, 7B |
| Sao Nicolau | SNE | Cape Verde | 144 km | 0h 40m | VR, 7B |
| Praia | RAI | Cape Verde | 206 km | 0h 50m | VR, HC, WK, 7B |
| Sao Vicente | VXE | Cape Verde | 225 km | 0h 55m | VR, WK, 7B |
| Sao Filipe | SFL | Cape Verde | 263 km | 0h 50m | VR, 7B |
| Dakar | DSS | Senegal | 669 km | 2h 0m | HC |
| Las Palmas | LPA | Spain | 1,463 km | 2h 10m | NT |
| Agadir | AGA | Morocco | 2,039 km | 2h 55m | TO |
| Casablanca | CMN | Morocco | 2,401 km | 3h 15m | AT |
| Lisbon | LIS | Portugal | 2,788 km | 3h 55m | TP, VR, U2, X9 |
| Porto | OPO | Portugal | 3,041 km | 4h 20m | U2 |
| Barcelona | BCN | Spain | 3,627 km | 4h 50m | VY |
| Bordeaux | BOD | France | 3,745 km | 5h 0m | TO |
| Toulouse | TLS | France | 3,761 km | 5h 0m | TO |
| Nantes | NTE | France | 3,902 km | 5h 10m | TO |
| Marseille | MRS | France | 3,978 km | 5h 15m | TO |
| Lyon | LYS | France | 4,134 km | 5h 30m | TO |
| Paris | ORY | France | 4,225 km | 5h 50m | TO |
| Bristol | BRS | United Kingdom | 4,242 km | 5h 40m | U2 |
| Paris | CDG | France | 4,258 km | 6h 0m | VR |
| London | LGW | United Kingdom | 4,320 km | 5h 45m | U2 |
| Milan | MXP | Italy | 4,346 km | 5h 40m | NO, U2 |
| Rome | FCO | Italy | 4,354 km | 5h 40m | NO |
| Birmingham | BHX | United Kingdom | 4,378 km | 5h 50m | |
| Milan | BGY | Italy | 4,411 km | 5h 55m | VR, NO |
| Leicestershire | EMA | United Kingdom | 4,428 km | 5h 40m | |
| Manchester | MAN | United Kingdom | 4,444 km | 6h 0m | U2 |
| Zurich | ZRH | Switzerland | 4,462 km | 6h 0m | WK |
| Verona | VRN | Italy | 4,471 km | 5h 40m | NO |
| Luxembourg | LUX | Luxembourg | 4,492 km | 6h 0m | LG |
| Brussels | BRU | Belgium | 4,506 km | 6h 45m | TB |
| Stuttgart | STR | Germany | 4,586 km | 6h 0m | X3 |
| Eindhoven | EIN | Netherlands | 4,595 km | 6h 35m | OR |
| Glasgow | GLA | United Kingdom | 4,617 km | 6h 10m | |
| Newcastle | NCL | United Kingdom | 4,622 km | 6h 20m | |
| Amsterdam | AMS | Netherlands | 4,635 km | 6h 40m | OR |
| Dusseldorf | DUS | Germany | 4,648 km | 6h 5m | X3 |
| Frankfurt | FRA | Germany | 4,649 km | 6h 15m | X3 |
| Munich | MUC | Germany | 4,715 km | 6h 10m | X3 |
| Hanover | HAJ | Germany | 4,885 km | 6h 15m | X3 |