Puerto Escondido offers nonstop service to 22 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Puebla | PBC | Mexico | 388 km | 0h 56m | Y4 |
| Mexico City | MEX | Mexico | 449 km | 1h 29m | AM, VB, Y4 |
| Mexico City | NLU | Mexico | 478 km | 1h 21m | VB |
| Guadalajara | GDL | Mexico | 837 km | 1h 40m | VB, Y4 |
| Monterrey | MTY | Mexico | 1,143 km | 2h 9m | VB |
| Houston | IAH | USA | 1,575 km | 2h 46m | UA |
| Dallas | DFW | USA | 1,888 km | 3h 24m | AA |
| Tijuana | TIJ | Mexico | 2,729 km | 4h 4m | Y4 |
| Toronto | YYZ | Canada | 3,500 km | 4h 50m | AC |
| Calgary | YYC | Canada | 4,195 km | 6h 0m | WS |
| Vancouver | YVR | Canada | 4,390 km | 6h 20m | AC |