Yangon International offers nonstop service to 38 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mawlamyine | MNU | Myanmar | 170 km | 0h 35m | ST, 7Y |
| Naypyidaw | NYT | Myanmar | 301 km | 1h 0m | UB, 8M |
| Chiang Mai | CNX | Thailand | 364 km | 1h 0m | 8M |
| Dawe | TVY | Myanmar | 380 km | 1h 10m | UB, 7Y, 8M, ST |
| Kyaukpyu | KYP | Myanmar | 392 km | 1h 10m | 8M |
| Heho | HEH | Myanmar | 431 km | 1h 15m | 7Y, 8M |
| Nyaung-u | NYU | Myanmar | 489 km | 1h 25m | 8M |
| Sittwe | AKY | Myanmar | 495 km | 1h 25m | 7Y, 8M |
| Mandalay | MDL | Myanmar | 531 km | 1h 5m | 8M, UB, 7Y |
| Myeik | MGZ | Myanmar | 560 km | 1h 35m | 8M, ST, 7Y |
| Tachilek | THL | Myanmar | 563 km | 1h 43m | 8M, ST, 7Y |
| Bangkok | DMK | Thailand | 582 km | 1h 20m | FD, 8M |
| Bangkok | BKK | Thailand | 609 km | 1h 20m | 8M, TG, UB |
| Keng Tung | KET | Myanmar | 609 km | 1h 45m | UB, 8M |
| Vientiane | VTE | Lao People's Democratic Republic | 693 km | 2h 15m | 8M |
| Kalemyo | KMV | Myanmar | 728 km | 1h 55m | 8M |
| Kawthaung | KAW | Myanmar | 800 km | 2h 10m | 8M |
| Myitkyina | MYT | Myanmar | 947 km | 2h 30m | 8M |
| Phuket | HKT | Thailand | 1,000 km | 1h 45m | 8M |
| Kolkata | CCU | India | 1,026 km | 1h 50m | 8M |
| Hanoi | HAN | Viet Nam | 1,123 km | 2h 0m | 8M |
| Phnom Penh | KTI | Cambodia | 1,129 km | 2h 0m | 8M |
| Kunming | KMG | China | 1,149 km | 2h 10m | MU |
| Da Nang | DAD | Viet Nam | 1,291 km | 2h 0m | 8M |
| Ho Chi Minh City | SGN | Viet Nam | 1,321 km | 2h 30m | 8M |
| Penang | PEN | Malaysia | 1,360 km | 2h 0m | 8M |
| Nanning | NNG | China | 1,409 km | 2h 30m | 8M |
| Gaya | GAY | India | 1,451 km | 2h 10m | 8M, UB |
| Kuala Lumpur | KUL | Malaysia | 1,680 km | 2h 45m | MH, 8M |
| Chennai | MAA | India | 1,771 km | 3h 15m | 8M |
| Chongqing | CKG | China | 1,778 km | 3h 0m | PN |
| Singapore | SIN | Singapore | 1,922 km | 3h 0m | 8M, SQ, UB |
| Guangzhou | CAN | China | 1,930 km | 3h 5m | 8M, CZ |
| Changsha | CSX | China | 2,152 km | 3h 0m | 8M |
| Delhi | DEL | India | 2,337 km | 3h 40m | 8M, AI |
| Beijing | PEK | China | 3,239 km | 5h 5m | CA |
| Seoul | ICN | Republic of Korea | 3,740 km | 5h 30m | KE, 8M |
| Dubai | DXB | United Arab Emirates | 4,319 km | 6h 15m | 8M |