Thiruvananthapuram International offers nonstop service to 25 destinations, served by 17 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Kochi | COK | India | 194 km | 0h 50m | 6E |
| Tiruchirappalli | TRZ | India | 320 km | 1h 20m | IX |
| Colombo | CMB | Sri Lanka | 357 km | 1h 0m | UL |
| Kannur | CNN | India | 409 km | 1h 0m | IX |
| Hanimaadhoo | HAQ | Maldives | 455 km | 1h 15m | Q2 |
| Bengaluru | BLR | India | 529 km | 1h 20m | 6E, IX |
| Mangalore | IXE | India | 543 km | 1h 20m | IX |
| Male | MLE | Maldives | 604 km | 1h 15m | Q2, 6E |
| Chennai | MAA | India | 611 km | 1h 20m | 6E |
| Hyderabad | HYD | India | 982 km | 1h 43m | 6E |
| Pune | PNQ | India | 1,164 km | 1h 55m | 6E |
| Mumbai | NMI | India | 1,234 km | 2h 10m | 6E |
| Mumbai | BOM | India | 1,253 km | 2h 25m | 6E, AI |
| Delhi | DEL | India | 2,222 km | 3h 30m | 6E, AI |
| Muscat | MCT | Oman | 2,597 km | 3h 55m | IX, WY |
| Kuala Lumpur | KUL | Malaysia | 2,818 km | 4h 15m | MH, AK |
| Sharjah | SHJ | United Arab Emirates | 2,936 km | 4h 15m | 6E, G9, IX |
| Dubai | DXB | United Arab Emirates | 2,944 km | 4h 20m | EK, IX |
| Abu Dhabi | AUH | United Arab Emirates | 2,953 km | 4h 15m | EY, IX, 3L |
| Singapore | SIN | Singapore | 3,101 km | 4h 45m | TR |
| Doha | DOH | Qatar | 3,262 km | 4h 40m | QR, IX |
| Bahrain | BAH | Bahrain | 3,404 km | 5h 0m | GF |
| Dammam | DMM | Saudi Arabia | 3,487 km | 5h 5m | IX |
| Riyadh | RUH | Saudi Arabia | 3,687 km | 6h 0m | IX |
| Kuwait | KWI | Kuwait | 3,798 km | 5h 15m | KU, J9 |