Libreville Leon M Ba offers nonstop service to 23 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Port Gentil | POG | Gabon | 149 km | 0h 35m | J7 |
| Bata | BSG | Equatorial Guinea | 166 km | 0h 35m | J7 |
| Oyem | OYE | Gabon | 269 km | 1h 0m | J7 |
| Sao Tome Island | TMS | Sao Tome and Principe | 298 km | 1h 0m | J7, KP |
| Malabo | SSG | Equatorial Guinea | 373 km | 0h 50m | J7 |
| Makokou | MKU | Gabon | 384 km | 1h 0m | J7 |
| Douala | DLA | Cameroon | 394 km | 1h 0m | J7, QC, WB |
| Yaounde | NSI | Cameroon | 430 km | 1h 15m | ET, J7 |
| Franceville | MVB | Gabon | 504 km | 1h 30m | J7 |
| Port Harcourt | PHC | Nigeria | 572 km | 1h 30m | J7 |
| Pointe Noire | PNR | Congo | 644 km | 1h 25m | J7, TK |
| Brazzaville | BZV | Congo | 833 km | 1h 35m | J7 |
| Kinshasa | FIH | The Democratic Republic of The Congo | 858 km | 1h 30m | J7 |
| Lagos | LOS | Nigeria | 956 km | 1h 40m | HF, J7 |
| Cotonou | COO | Benin | 1,016 km | 1h 40m | QC, HF, J7, HC |
| Bangui | BGF | Central African Republic | 1,102 km | 1h 45m | J7 |
| Lome | LFW | Togo | 1,104 km | 2h 0m | KP |
| Abidjan | ABJ | Cote d'Ivoire | 1,575 km | 2h 30m | HF |
| Addis Ababa | ADD | Ethiopia | 3,390 km | 4h 45m | ET |
| Johannesburg | JNB | South Africa | 3,570 km | 4h 45m | KP, J7 |
| Casablanca | CMN | Morocco | 4,053 km | 5h 40m | AT |
| Istanbul | IST | Turkiye | 4,920 km | 7h 25m | TK |
| Paris | CDG | France | 5,419 km | 8h 3m | AF |