Yaounde Nsimalen offers nonstop service to 16 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Douala | DLA | Cameroon | 206 km | 0h 45m | AT, HF, QC, TK, J7 |
| Bata | BSG | Equatorial Guinea | 277 km | 1h 0m | J7 |
| Malabo | SSG | Equatorial Guinea | 314 km | 1h 0m | KP |
| Libreville | LBV | Gabon | 430 km | 1h 10m | ET, J7, AF |
| Garoua | GOU | Cameroon | 654 km | 1h 15m | QC |
| Abuja | ABV | Nigeria | 753 km | 1h 25m | HF, QC |
| Bangui | BGF | Central African Republic | 777 km | 1h 15m | J7 |
| Maroua | MVR | Cameroon | 804 km | 1h 30m | QC |
| Ndjamena | NDJ | Chad | 1,007 km | 1h 40m | QC, KP |
| Lome | LFW | Togo | 1,174 km | 2h 0m | KP |
| Abidjan | ABJ | Cote d'Ivoire | 1,726 km | 2h 40m | HF |
| Addis Ababa | ADD | Ethiopia | 3,069 km | 4h 5m | ET |
| Casablanca | CMN | Morocco | 3,839 km | 5h 30m | AT |
| Istanbul | IST | Turkiye | 4,501 km | 7h 5m | TK |
| Paris | CDG | France | 5,092 km | 7h 50m | AF |
| Brussels | BRU | Belgium | 5,272 km | 6h 40m | SN |