Yaounde Nsimalen offers nonstop service to 26 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Douala | DLA | Cameroon | 206 km | 0h 45m | AT, HF, J7, TK |
| Bata | BSG | Equatorial Guinea | 277 km | 0h 55m | J7 |
| Malabo | SSG | Equatorial Guinea | 314 km | 1h 0m | KP |
| Libreville | LBV | Gabon | 430 km | 1h 15m | ET, J7 |
| Bangui | BGF | Central African Republic | 777 km | 1h 20m | J7, KP |
| Lagos | LOS | Nigeria | 966 km | 2h 0m | KP |
| Ndjamena | NDJ | Chad | 1,007 km | 1h 40m | KP |
| Lome | LFW | Togo | 1,174 km | 2h 0m | KP |
| Abidjan | ABJ | Cote d'Ivoire | 1,726 km | 2h 40m | HF |
| Addis Ababa | ADD | Ethiopia | 3,069 km | 4h 5m | ET |
| Casablanca | CMN | Morocco | 3,839 km | 5h 30m | AT |
| Istanbul | IST | Turkiye | 4,501 km | 6h 55m | TK |
| Paris | CDG | France | 5,092 km | 7h 50m | AF |
| Brussels | BRU | Belgium | 5,272 km | 6h 40m | SN |