Cotonou Cadjehoun offers nonstop service to 16 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Lagos | LOS | Nigeria | 106 km | 0h 30m | KP, VK, J7 |
| Lome | LFW | Togo | 127 km | 0h 40m | 2J, AT, KP, ET |
| Accra | ACC | Ghana | 294 km | 1h 5m | SN, HF |
| Abidjan | ABJ | Cote d'Ivoire | 710 km | 1h 25m | HF, TK, HC |
| Malabo | SSG | Equatorial Guinea | 758 km | 1h 20m | J7, VK |
| Ouagadougou | OUA | Burkina Faso | 789 km | 1h 30m | 2J |
| Douala | DLA | Cameroon | 853 km | 1h 30m | HC, ET |
| Libreville | LBV | Gabon | 1,016 km | 1h 40m | HF, QC, J7, HC |
| Bamako | BKO | Mali | 1,324 km | 2h 20m | SS |
| Dakar | DSS | Senegal | 2,317 km | 3h 30m | HC |
| Casablanca | CMN | Morocco | 3,163 km | 4h 25m | AT |
| Addis Ababa | ADD | Ethiopia | 4,026 km | 5h 40m | ET |
| Istanbul | IST | Turkiye | 4,667 km | 6h 35m | TK |
| Paris | ORY | France | 4,696 km | 6h 40m | SS |
| Paris | CDG | France | 4,727 km | 6h 45m | AF |
| Brussels | BRU | Belgium | 4,941 km | 6h 30m | SN |