Douala offers nonstop service to 24 destinations, served by 16 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Malabo | SSG | Equatorial Guinea | 114 km | 0h 45m | ET, C2, J7 |
| Bafoussam | BFX | Cameroon | 182 km | 0h 45m | QC |
| Yaounde | NSI | Cameroon | 206 km | 0h 45m | AT, HF, QC, SN, TK |
| Bata | BSG | Equatorial Guinea | 233 km | 0h 50m | J7 |
| Port Harcourt | PHC | Nigeria | 326 km | 1h 0m | J7 |
| Libreville | LBV | Gabon | 394 km | 1h 0m | J7, QC, WB |
| Ngaoundere | NGE | Cameroon | 564 km | 1h 15m | QC |
| Abuja | ABV | Nigeria | 614 km | 1h 15m | HF, AH |
| Lagos | LOS | Nigeria | 763 km | 1h 30m | QC |
| Cotonou | COO | Benin | 853 km | 1h 30m | HC, ET |
| Lome | LFW | Togo | 968 km | 1h 45m | KP |
| Bangui | BGF | Central African Republic | 978 km | 1h 50m | AT, KP, QC, WB, HF |
| Ndjamena | NDJ | Chad | 1,071 km | 1h 50m | HF, KP, QC, AH, CH |
| Brazzaville | BZV | Congo | 1,102 km | 1h 50m | QC |
| Kinshasa | FIH | The Democratic Republic of The Congo | 1,126 km | 1h 45m | ET |
| Abidjan | ABJ | Cote d'Ivoire | 1,520 km | 2h 30m | HF, KQ |
| Kigali | KGL | Rwanda | 2,365 km | 4h 30m | WB |
| Nairobi | NBO | Kenya | 3,083 km | 4h 20m | KQ |
| Addis Ababa | ADD | Ethiopia | 3,261 km | 4h 30m | ET |
| Algiers | ALG | Algeria | 3,680 km | 5h 0m | AH |
| Cairo | CAI | Egypt | 3,681 km | 5h 5m | MS |
| Casablanca | CMN | Morocco | 3,713 km | 5h 20m | AT |
| Istanbul | IST | Turkiye | 4,542 km | 6h 50m | TK |
| Paris | CDG | France | 5,032 km | 7h 45m | AF |