Douala offers nonstop service to 35 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Malabo | SSG | Equatorial Guinea | 114 km | 0h 45m | C2, ET, J7, KP |
| Yaounde | NSI | Cameroon | 206 km | 0h 45m | AT, HF, SN, TK |
| Bata | BSG | Equatorial Guinea | 233 km | 0h 50m | C2, J7 |
| Port Harcourt | PHC | Nigeria | 326 km | 0h 55m | J7 |
| Libreville | LBV | Gabon | 394 km | 1h 0m | AH, J7, P4, WB |
| Abuja | ABV | Nigeria | 614 km | 1h 15m | AH, HF |
| Lagos | LOS | Nigeria | 763 km | 1h 30m | P4 |
| Lome | LFW | Togo | 968 km | 1h 45m | KP |
| Bangui | BGF | Central African Republic | 978 km | 1h 50m | AT, CH, KP, WB |
| Ndjamena | NDJ | Chad | 1,071 km | 1h 50m | CH, KP |
| Kigali | KGL | Rwanda | 2,365 km | 4h 25m | WB |
| Addis Ababa | ADD | Ethiopia | 3,261 km | 4h 30m | ET |
| Algiers | ALG | Algeria | 3,680 km | 5h 3m | AH |
| Cairo | CAI | Egypt | 3,681 km | 5h 10m | MS |
| Casablanca | CMN | Morocco | 3,713 km | 5h 30m | AT |
| Istanbul | IST | Turkiye | 4,542 km | 6h 48m | TK |
| Paris | CDG | France | 5,032 km | 7h 30m | AF |