Hotan offers nonstop service to 56 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Shache | QSZ | China | 282 km | 0h 50m | G5 |
| Tumushuke | TWC | China | 320 km | 0h 55m | EU |
| Alaer | ACF | China | 395 km | 1h 3m | G5 |
| Kashi | KHG | China | 436 km | 1h 10m | CZ, EU |
| Aksu | AKU | China | 469 km | 1h 5m | G5 |
| Qiemo | IQM | China | 514 km | 1h 5m | G5 |
| Shi Quan He | NGQ | China | 547 km | 1h 30m | 8L |
| Kuqa | KCA | China | 584 km | 1h 15m | G5 |
| Zhaosu | ZFL | China | 681 km | 1h 35m | G5 |
| Korla | KRL | China | 741 km | 1h 45m | CZ |
| Ruogiang | RQA | China | 745 km | 1h 10m | EU |
| Yining | YIN | China | 777 km | 1h 35m | EU |
| Bole | BPL | China | 895 km | 1h 40m | EU, UQ |
| Shihezi | SHF | China | 947 km | 1h 45m | EU, G5 |
| Urumqi | URC | China | 997 km | 1h 55m | 8L, CZ, GS, HU, UQ |
| Turpan | TLQ | China | 1,027 km | 2h 0m | EU |
| Karamay | KRY | China | 1,040 km | 1h 55m | UQ |
| Tacheng | TCG | China | 1,107 km | 2h 0m | EU |
| Hami | HMI | China | 1,325 km | 2h 25m | EU |
| Altay | AAT | China | 1,366 km | 2h 15m | EU |
| Lanzhou | LHW | China | 2,115 km | 3h 20m | 9C, QW, UQ |
| Chengdu | TFU | China | 2,389 km | 4h 10m | CA |
| Chongqing | CKG | China | 2,609 km | 4h 20m | CA, PN |
| Xian | XIY | China | 2,619 km | 3h 40m | MU |
| Zhengzhou | CGO | China | 3,067 km | 4h 30m | CZ |
| Beijing | PKX | China | 3,187 km | 5h 0m | CZ |
| Beijing | PEK | China | 3,195 km | 4h 55m | CA |
| Wuhan | WUH | China | 3,232 km | 4h 35m | EU |