Karamay Airport offers nonstop service to 32 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bole | BPL | China | 218 km | 0h 45m | G5 |
| Urumqi | URC | China | 280 km | 0h 58m | EU, UQ |
| Yining | YIN | China | 336 km | 0h 58m | CA, G5 |
| Zhaosu | ZFL | China | 404 km | 1h 5m | G5 |
| Turpan | TLQ | China | 441 km | 1h 0m | EU |
| Korla | KRL | China | 455 km | 1h 15m | G5 |
| Kuqa | KCA | China | 459 km | 1h 10m | EU |
| Aksu | AKU | China | 610 km | 1h 20m | G5 |
| Hotan | HTN | China | 1,040 km | 1h 50m | UQ |
| Shache | QSZ | China | 1,043 km | 2h 0m | EU |
| Lanzhou | LHW | China | 1,864 km | 3h 5m | 9C |
| Yinchuan | INC | China | 1,949 km | 3h 15m | GJ |
| Xian | XIY | China | 2,372 km | 3h 30m | MU |
| Chengdu | TFU | China | 2,403 km | 3h 40m | 3U, CA |
| Beijing | PEK | China | 2,644 km | 3h 55m | CA |
| Zhengzhou | CGO | China | 2,739 km | 4h 5m | GJ |