Wilmington International offers nonstop service to 26 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 296 km | 1h 18m | AA |
| Washington | DCA | USA | 514 km | 1h 32m | AA |
| Baltimore | BWI | USA | 556 km | 1h 20m | XP |
| Atlanta | ATL | USA | 607 km | 1h 38m | DL |
| Wilmington | ILG | USA | 634 km | 1h 21m | XP |
| Philadelphia | PHL | USA | 666 km | 1h 42m | AA |
| Orlando | MCO | USA | 723 km | 1h 50m | MX |
| New York | EWR | USA | 785 km | 2h 0m | UA |
| Akron | CAK | USA | 800 km | 1h 44m | MX |
| New York | LGA | USA | 805 km | 1h 49m | AA, DL |
| Nashville | BNA | USA | 823 km | 1h 43m | XP |
| Tampa | TPA | USA | 824 km | 1h 51m | XP, MX |
| Islip | ISP | USA | 839 km | 1h 37m | MX |
| New Haven | HVN | USA | 893 km | 1h 41m | XP |
| Fort Myers | RSW | USA | 933 km | 2h 0m | MX |
| Fort Lauderdale | FLL | USA | 933 km | 2h 0m | MX |
| Hartford | BDL | USA | 965 km | 1h 49m | MX |
| Miami | MIA | USA | 966 km | 2h 0m | AA |
| Rochester | ROC | USA | 983 km | 1h 50m | XP |
| Providence | PVD | USA | 1,003 km | 1h 50m | MX |
| Boston | BOS | USA | 1,081 km | 2h 9m | AA, DL, B6 |
| Chicago | ORD | USA | 1,223 km | 2h 43m | AA, UA |
| New Orleans | MSY | USA | 1,256 km | 2h 35m | MX |
| Minneapolis | MSP | USA | 1,760 km | 2h 54m | SY, DL |
| Dallas | DFW | USA | 1,779 km | 3h 26m | AA |
| Denver | DEN | USA | 2,449 km | 4h 25m | UA |