Ndjamena offers nonstop service to 10 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Abecher | AEH | Chad | 659 km | 2h 8m | CH |
| Abuja | ABV | Nigeria | 917 km | 1h 45m | KP |
| Yaounde | NSI | Cameroon | 1,007 km | 1h 40m | QC, KP, AF |
| Douala | DLA | Cameroon | 1,071 km | 1h 50m | HF, KP, QC, AF, AH, CH |
| Niamey | NIM | Niger | 1,403 km | 2h 20m | TK, KP |
| Cairo | CAI | Egypt | 2,612 km | 3h 35m | MS |
| Addis Ababa | ADD | Ethiopia | 2,622 km | 4h 0m | ET, AH |
| Algiers | ALG | Algeria | 2,968 km | 4h 25m | AH |
| Casablanca | CMN | Morocco | 3,290 km | 5h 20m | AT |
| Istanbul | IST | Turkiye | 3,494 km | 5h 25m | TK |