Ndjamena offers nonstop service to 27 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Moundou | MQQ | Chad | 403 km | 1h 5m | CH |
| Sarh | SRH | Chad | 497 km | 1h 15m | CH |
| Abecher | AEH | Chad | 659 km | 1h 40m | CH |
| Faya | FYT | Chad | 776 km | 1h 50m | CH |
| Abuja | ABV | Nigeria | 917 km | 1h 45m | KP |
| Bangui | BGF | Central African Republic | 937 km | 1h 50m | CH |
| Yaounde | NSI | Cameroon | 1,007 km | 1h 40m | AF, KP |
| Douala | DLA | Cameroon | 1,071 km | 1h 50m | CH, KP |
| Niamey | NIM | Niger | 1,403 km | 2h 10m | TK |
| Cairo | CAI | Egypt | 2,612 km | 3h 35m | MS |
| Addis Ababa | ADD | Ethiopia | 2,622 km | 4h 0m | AH, ET |
| Algiers | ALG | Algeria | 2,968 km | 4h 25m | AH |
| Casablanca | CMN | Morocco | 3,290 km | 5h 20m | AT |
| Istanbul | IST | Turkiye | 3,494 km | 5h 30m | TK |