Dehong Mangshi Airport offers nonstop service to 27 destinations, served by 15 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Lijiang | LJG | China | 305 km | 1h 0m | DR |
| Jinghong | JHG | China | 353 km | 0h 55m | DR |
| Mandalay | MDL | Myanmar | 397 km | 1h 10m | DR, UB |
| Kunming | KMG | China | 451 km | 1h 10m | 8L, DR, KY, MU, TV, 9C, LT |
| Guiyang | KWE | China | 863 km | 1h 35m | GY, DR |
| Chengdu | CTU | China | 869 km | 1h 40m | TV |
| Chengdu | TFU | China | 877 km | 1h 45m | 3U, CA, MU, KY, GY, OQ |
| Chongqing | CKG | China | 996 km | 1h 55m | DR, 3U, KY |
| Xian | XIY | China | 1,488 km | 2h 30m | MU |
| Guangzhou | CAN | China | 1,507 km | 2h 33m | MU, CZ, OQ |
| Changsha | CSX | China | 1,523 km | 2h 25m | DR, KY, A6 |
| Shenzhen | SZX | China | 1,571 km | 2h 35m | TV |
| Huizhou | HUZ | China | 1,643 km | 2h 50m | DR |
| Wuhan | WUH | China | 1,699 km | 2h 30m | DR |
| Nanchang | KHN | China | 1,797 km | 2h 30m | A6, DR |
| Jieyang | SWA | China | 1,830 km | 2h 30m | DR |
| Zhengzhou | CGO | China | 1,857 km | 3h 8m | KY |
| Hefei | HFE | China | 1,992 km | 2h 35m | DR |
| Jinjiang | JJN | China | 2,029 km | 2h 40m | DR |
| Fuzhou | FOC | China | 2,135 km | 2h 50m | DR |
| Nanjing | NKG | China | 2,153 km | 2h 40m | MU, DR |
| Changzhou | CZX | China | 2,241 km | 3h 10m | DR |
| Hangzhou | HGH | China | 2,257 km | 2h 55m | KY, 3U |
| Wuxi | WUX | China | 2,287 km | 3h 25m | MU |
| Ningbo | NGB | China | 2,347 km | 3h 30m | DR, GJ |
| Beijing | PKX | China | 2,370 km | 3h 50m | MU |
| Shanghai | PVG | China | 2,406 km | 3h 25m | MU |