Mandalay International offers nonstop service to 28 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Naypyidaw | NYT | Myanmar | 231 km | 0h 35m | UB |
| Kalemyo | KMV | Myanmar | 257 km | 0h 50m | 8M, ST |
| Homalin | HOX | Myanmar | 370 km | 1h 5m | 7Y, 8M, ST |
| Keng Tung | KET | Myanmar | 379 km | 1h 10m | 8M |
| Mangshi | LUM | China | 397 km | 1h 20m | DR |
| Myitkyina | MYT | Myanmar | 431 km | 1h 20m | 7Y, 8M, ST |
| Tachilek | THL | Myanmar | 432 km | 1h 10m | 7Y, ST |
| Chiang Mai | CNX | Thailand | 450 km | 1h 20m | 8M |
| Khamti | KHM | Myanmar | 475 km | 1h 15m | 7Y |
| Yangon | RGN | Myanmar | 531 km | 1h 25m | 7Y, 8M, UB |
| Putao | PBU | Myanmar | 640 km | 1h 40m | 7Y |
| Kunming | KMG | China | 803 km | 1h 40m | MU |
| Bangkok | DMK | Thailand | 991 km | 1h 50m | 8M |
| Bangkok | BKK | Thailand | 1,020 km | 1h 50m | 8M |