Hefei Xinqiao Airport offers nonstop service to 125 destinations, served by 25 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Shanghai | PVG | China | 468 km | 1h 15m | MU |
| Qingdao | TAO | China | 563 km | 1h 20m | JD, MU, QW, SC |
| Wenzhou | WNZ | China | 586 km | 1h 30m | AQ, MU |
| Yuncheng | YCU | China | 650 km | 1h 30m | MF, MU |
| Dayong | DYG | China | 703 km | 1h 40m | AQ |
| Ganzhou | KOW | China | 713 km | 1h 45m | MU |
| Fuzhou | FOC | China | 721 km | 1h 45m | MU |
| Shijiazhuang | SJW | China | 727 km | 1h 35m | MU |
| Yantai | YNT | China | 727 km | 1h 35m | MU |
| Weihai | WEH | China | 751 km | 1h 45m | MU |
| Taiyuan | TYN | China | 752 km | 1h 35m | HU, MU, PN, ZH |
| Xian | XIY | China | 811 km | 1h 50m | CZ, MU, ZH |
| Jinjiang | JJN | China | 812 km | 1h 35m | MF, MU, ZH |
| Xiamen | XMN | China | 833 km | 1h 45m | HU, MF, MU, SC |
| Beijing | PKX | China | 835 km | 1h 45m | CZ, MU |
| Tongren | TEN | China | 869 km | 2h 3m | GY |
| Dalian | DLC | China | 876 km | 1h 45m | HU, MU, PN |
| Beijing | PEK | China | 897 km | 1h 55m | CA |
| Jieyang | SWA | China | 936 km | 1h 55m | 9C, MU |
| Datong | DAT | China | 948 km | 2h 30m | MU |
| Guilin | KWL | China | 1,010 km | 1h 55m | GT, MU, SC |
| Huizhou | HUZ | China | 1,018 km | 2h 15m | MU |
| Guangzhou | CAN | China | 1,019 km | 2h 10m | AQ, CZ, HU, MU, ZH |
| Chongqing | CKG | China | 1,019 km | 2h 0m | 3U, CA, MU, PN |
| Nanchong | NAO | China | 1,045 km | 2h 15m | GX |
| Dongsheng | DSN | China | 1,051 km | 2h 5m | MU |
| Seoul | ICN | Republic of Korea | 1,057 km | 2h 35m | KE |
| Guangyuan | GYS | China | 1,063 km | 2h 15m | TV |
| Zunyi | ZYI | China | 1,080 km | 2h 5m | 8L |
| Shenzhen | SZX | China | 1,082 km | 2h 20m | CZ, DZ, PN, ZH |
| Hohhot | HET | China | 1,086 km | 2h 5m | JD, MU, PN |
| Hong Kong | HKG | Hong Kong SAR | 1,113 km | 2h 38m | MU |
| Liuzhou | LZH | China | 1,138 km | 2h 10m | FM, MU |
| Libo City | LLB | China | 1,139 km | 2h 5m | GY |
| Macau | MFM | Macau SAR | 1,140 km | 2h 30m | MU |
| Guiyang | KWE | China | 1,158 km | 2h 15m | AQ, JD, MU, PN, QW |
| Mian Yang | MIG | China | 1,159 km | 2h 15m | ZH |
| Zhuhai | ZUH | China | 1,162 km | 2h 15m | CZ, HU, LT, PN |
| Yinchuan | INC | China | 1,191 km | 2h 15m | MF, MU |
| Chengdu | TFU | China | 1,208 km | 2h 20m | 3U, CA, EU, MU, PN, QW, ZH |
| Shenyang | SHE | China | 1,216 km | 2h 30m | 9C, EU, HU, MU, ZH |
| Yibin | YBP | China | 1,244 km | 2h 30m | ZH |
| Chengdu | CTU | China | 1,248 km | 2h 25m | 3U, CA, EU, TV |
| Lanzhou | LHW | China | 1,326 km | 2h 30m | 9C, MU |
| Nanning | NNG | China | 1,355 km | 2h 30m | MU, QW, ZH |
| Zhanjiang | ZHA | China | 1,362 km | 2h 30m | MU |
| Beihai | BHY | China | 1,386 km | 2h 45m | MU |
| Xining | XNN | China | 1,462 km | 2h 40m | MU |
| Haikou | HAK | China | 1,485 km | 2h 40m | HU |
| Xichang | XIC | China | 1,492 km | 3h 0m | GY |
| Changchun | CGQ | China | 1,534 km | 2h 35m | FM, HU, MU, QW, ZH |
| Kunming | KMG | China | 1,570 km | 2h 45m | 3U, 8L, BK, MU, PN |
| Sanya | SYX | China | 1,695 km | 2h 50m | EU, HU, JD |
| Harbin | HRB | China | 1,710 km | 3h 5m | 3U, EU, LT, MU, ZH |
| Lijiang | LJG | China | 1,725 km | 2h 55m | QW |
| Hailar | HLD | China | 1,926 km | 3h 15m | AQ, PN |
| Jinghong | JHG | China | 1,950 km | 3h 10m | 3U, MU |
| Mangshi | LUM | China | 1,992 km | 3h 10m | DR |
| Vientiane | VTE | Lao People's Democratic Republic | 2,122 km | 3h 30m | AQ |
| Urumqi | URC | China | 2,888 km | 4h 45m | CZ, MU |
| Yining | YIN | China | 3,368 km | 5h 25m | 9C |
| Singapore | SIN | Singapore | 3,654 km | 5h 20m | MU |