La Romana International offers nonstop service to 32 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Holguin | HOG | Cuba | 820 km | 1h 35m | NO |
| Montego Bay | MBJ | Jamaica | 952 km | 1h 50m | NO |
| Miami | MIA | USA | 1,429 km | 2h 37m | AA |
| Havana | HAV | Cuba | 1,494 km | 2h 20m | NO |
| Montreal | YUL | Canada | 3,032 km | 4h 35m | AC, TS |
| Madrid | MAD | Spain | 6,633 km | 8h 5m | E9 |
| Lyon | LYS | France | 7,332 km | 8h 20m | NO |
| Marseille | MRS | France | 7,355 km | 8h 30m | NO |
| Dusseldorf | DUS | Germany | 7,439 km | 8h 55m | DE |
| Frankfurt | FRA | Germany | 7,572 km | 9h 5m | DE |
| Milan | MXP | Italy | 7,615 km | 8h 50m | NO |
| Cagliari | CAG | Italy | 7,719 km | 8h 55m | NO |
| Verona | VRN | Italy | 7,788 km | 8h 55m | NO |
| Rome | FCO | Italy | 7,947 km | 9h 0m | NO |
| Palermo | PMO | Italy | 8,084 km | 9h 20m | NO |
| Bari | BRI | Italy | 8,331 km | 9h 30m | NO |