Trapani Birgi offers nonstop service to 24 destinations, served by 1 airline.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Malta | MLA | Malta | 289 km | 0h 50m | FR |
| Rome | FCO | Italy | 432 km | 1h 15m | FR |
| Bari | BRI | Italy | 513 km | 1h 20m | FR |
| Pescara | PSR | Italy | 523 km | 1h 10m | FR |
| Pisa | PSA | Italy | 667 km | 1h 20m | FR |
| Bologna | BLQ | Italy | 742 km | 1h 30m | FR |
| Verona | VRN | Italy | 843 km | 1h 45m | FR |
| Venice | VCE | Italy | 844 km | 1h 35m | FR |
| Milan | BGY | Italy | 892 km | 1h 40m | FR |
| Turin | TRN | Italy | 904 km | 1h 40m | FR |
| Milan | MXP | Italy | 913 km | 1h 45m | FR |
| Bratislava | BTS | Slovakia | 1,203 km | 2h 0m | FR |
| Karlsruhe/Baden-Baden | FKB | Germany | 1,259 km | 2h 5m | FR |
| Saarbruecken | SCN | Germany | 1,329 km | 2h 25m | FR |
| Katowice | KTW | Poland | 1,490 km | 2h 25m | FR |
| Brussels | CRL | Belgium | 1,534 km | 2h 30m | FR |
| Dusseldorf | NRN | Germany | 1,601 km | 2h 35m | FR |
| Sevilla | SVQ | Spain | 1,621 km | 2h 40m | FR |
| Swidnik | LUZ | Poland | 1,684 km | 2h 45m | FR |
| Bournemouth | BOH | United Kingdom | 1,824 km | 3h 0m | FR |
| London | STN | United Kingdom | 1,824 km | 3h 0m | FR |
| Porto | OPO | Portugal | 1,851 km | 3h 0m | FR |
| Manchester | MAN | United Kingdom | 2,059 km | 3h 10m | FR |
| Stockholm | ARN | Sweden | 2,449 km | 3h 40m | FR |