Karlsruhe/Badern Baden offers nonstop service to 42 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| London | STN | United Kingdom | 655 km | 1h 30m | FR |
| Wroclaw | WRO | Poland | 682 km | 1h 25m | W6 |
| Zagreb | ZAG | Croatia | 691 km | 1h 30m | FR |
| Zadar | ZAD | Croatia | 762 km | 1h 30m | FR |
| Banja Luka | BNX | Bosnia and Herzegovina | 821 km | 1h 35m | FR |
| Girona | GRO | Spain | 870 km | 1h 39m | FR |
| Sarajevo | SJJ | Bosnia and Herzegovina | 961 km | 1h 35m | FR |
| Belgrade | BEG | Republic of Serbia | 1,028 km | 1h 50m | W6 |
| Dubrovnik | DBV | Croatia | 1,050 km | 1h 45m | FR |
| Timisoara | TSR | Romania | 1,052 km | 1h 55m | W4 |
| Cagliari | CAG | Italy | 1,061 km | 1h 55m | FR |
| Bari | BRI | Italy | 1,089 km | 2h 0m | FR |
| Palma de Mallorca | PMI | Spain | 1,111 km | 1h 55m | EW, FR |
| Podgorica | TGD | Montenegro | 1,123 km | 2h 0m | W6 |
| Tirana | TIA | Albania | 1,224 km | 2h 10m | W4, FR |
| Valencia | VLC | Spain | 1,237 km | 2h 5m | FR |
| Palermo | PMO | Italy | 1,244 km | 2h 5m | FR |
| Targu-Mures | TGM | Romania | 1,250 km | 2h 10m | W4 |
| Sibiu | SBZ | Romania | 1,252 km | 2h 5m | W4 |
| Trapani | TPS | Italy | 1,259 km | 2h 10m | FR |
| Lamezia-Terme | SUF | Italy | 1,276 km | 2h 15m | FR |
| Skopje | SKP | North Macedonia | 1,300 km | 2h 15m | W6 |
| Alicante | ALC | Spain | 1,357 km | 2h 20m | FR |
| Suceava | SCV | Romania | 1,358 km | 2h 15m | W4 |
| Stockholm | ARN | Sweden | 1,366 km | 2h 20m | FR |
| Sofia | SOF | Bulgaria | 1,367 km | 2h 20m | FR |
| Kerkyra | CFU | Greece | 1,386 km | 2h 20m | FR |
| Bucharest | BBU | Romania | 1,453 km | 2h 30m | FR, W4 |
| Thessaloniki | SKG | Greece | 1,490 km | 2h 25m | FR |
| Porto | OPO | Portugal | 1,559 km | 2h 35m | FR |
| Chisinau | RMO | Republic of Moldova | 1,568 km | 2h 30m | W4 |
| Malaga | AGP | Spain | 1,689 km | 2h 48m | FR |
| Sevilla | SVQ | Spain | 1,694 km | 2h 40m | FR |
| Faro | FAO | Portugal | 1,843 km | 2h 55m | FR |
| Tangier | TNG | Morocco | 1,847 km | 2h 58m | FR |
| Fes | FEZ | Morocco | 1,972 km | 3h 15m | FR |
| Rabat | RBA | Morocco | 2,046 km | 3h 5m | FR |
| Antalya | AYT | Turkiye | 2,263 km | 3h 30m | FH, XC |
| Agadir | AGA | Morocco | 2,528 km | 3h 55m | FR |
| Amman | AMM | Jordan | 3,007 km | 4h 20m | FR |
| Las Palmas | LPA | Spain | 3,067 km | 4h 30m | FR |
| Tenerife | TFS | Spain | 3,124 km | 4h 35m | FR |