Lampedusa offers nonstop service to 22 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Trapani | TPS | Italy | 266 km | 0h 50m | BN |
| Palermo | PMO | Italy | 301 km | 1h 5m | DX |
| Catania | CTA | Italy | 309 km | 1h 5m | DX |
| Naples | NAP | Italy | 615 km | 1h 30m | U2, V7 |
| Rome | FCO | Italy | 699 km | 1h 40m | W4 |
| Bologna | BLQ | Italy | 1,008 km | 1h 55m | V7 |
| Verona | VRN | Italy | 1,109 km | 1h 55m | V7 |
| Venice | VCE | Italy | 1,110 km | 2h 0m | V7 |
| Milan | LIN | Italy | 1,141 km | 2h 0m | V7 |
| Milan | BGY | Italy | 1,155 km | 2h 0m | V7 |
| Milan | MXP | Italy | 1,171 km | 2h 5m | U2, W4 |