Islamabad International Airport offers nonstop service to 78 destinations, served by 30 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Lahore | LHE | Pakistan | 269 km | 0h 45m | 9P |
| Gilgit | GIL | Pakistan | 297 km | 1h 15m | PK |
| Skardu | KDU | Pakistan | 318 km | 1h 0m | PA, PF, PK |
| Kabul | KBL | Afghanistan | 351 km | 1h 10m | FG, RQ |
| Multan | MUX | Pakistan | 394 km | 1h 45m | SQB |
| Bahawalpur | BHV | Pakistan | 472 km | 1h 40m | SQB |
| Rahim Yar Khan | RYK | Pakistan | 620 km | 2h 15m | SQB |
| Quetta | UET | Pakistan | 665 km | 1h 25m | 9P, PK |
| Kashi | KHG | China | 723 km | 1h 50m | CZ |
| Sukkur | SKZ | Pakistan | 752 km | 2h 18m | PK, SQB |
| Tashkent | TAS | Uzbekistan | 911 km | 2h 0m | HY |
| Karachi | KHI | Pakistan | 1,104 km | 2h 0m | 9P, CA, PA, PF, PK |
| Urumqi | URC | China | 1,710 km | 2h 40m | CZ |
| Muscat | MCT | Oman | 1,796 km | 3h 15m | OV, PF, PK |
| Ras al-Khaimah | RKT | United Arab Emirates | 1,853 km | 3h 5m | G9 |
| Sharjah | SHJ | United Arab Emirates | 1,906 km | 3h 15m | 9P, PA, PK |
| Dubai | DXB | United Arab Emirates | 1,923 km | 3h 25m | EK, FZ, PA, PF, PK |
| Al Ain | AAN | United Arab Emirates | 1,964 km | 3h 15m | PK |
| Tehran | IKA | Iran | 1,997 km | 3h 45m | B9, W5 |
| Abu Dhabi | AUH | United Arab Emirates | 2,035 km | 3h 20m | EY, PA, PF, PK |
| Baku | GYD | Azerbaijan | 2,159 km | 3h 35m | J2 |
| Doha | DOH | Qatar | 2,248 km | 3h 45m | PK, QR |
| Bahrain | BAH | Bahrain | 2,284 km | 4h 0m | 9P, GF |
| Dammam | DMM | Saudi Arabia | 2,349 km | 4h 5m | 9P, PA, PF, PK |
| Kuwait | KWI | Kuwait | 2,405 km | 4h 15m | J9, KU |
| Baghdad | BGW | Iraq | 2,651 km | 5h 0m | IA |
| Riyadh | RUH | Saudi Arabia | 2,702 km | 4h 40m | 9P, F3, PA, PF, PK, RX, SV, XY |
| Gassim | ELQ | Saudi Arabia | 2,907 km | 5h 15m | PK |
| Madinah | MED | Saudi Arabia | 3,360 km | 5h 25m | PK |
| Jeddah | JED | Saudi Arabia | 3,555 km | 5h 40m | 9P, PA, PF, PK, SV |
| Bangkok | BKK | Thailand | 3,578 km | 5h 5m | TG |
| Beijing | PEK | China | 3,931 km | 5h 33m | CA, PK |
| Istanbul | IST | Turkiye | 3,951 km | 6h 15m | TK |
| Guangzhou | CAN | China | 4,092 km | 5h 45m | CZ |
| Paris | CDG | France | 5,906 km | 8h 35m | PK |
| London | LGW | United Kingdom | 6,053 km | 8h 55m | BA |
| London | LHR | United Kingdom | 6,065 km | 8h 40m | PK |
| Manchester | MAN | United Kingdom | 6,146 km | 8h 45m | PK |
| Toronto | YYZ | Canada | 11,007 km | 14h 0m | PK |