Islamabad International Airport offers nonstop service to 39 destinations, served by 29 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Lahore | LHE | Pakistan | 269 km | 0h 40m | PK |
| Gilgit | GIL | Pakistan | 297 km | 1h 15m | PK |
| Skardu | KDU | Pakistan | 318 km | 1h 0m | PK, PA |
| Kabul | KBL | Afghanistan | 351 km | 1h 10m | RQ, FG |
| Quetta | UET | Pakistan | 665 km | 1h 25m | PK, 9P |
| Kashi | KHG | China | 723 km | 1h 50m | CZ |
| Sukkur | SKZ | Pakistan | 752 km | 2h 20m | PK |
| Tashkent | TAS | Uzbekistan | 911 km | 2h 0m | HY |
| Bishkek | BSZ | Kyrgyzstan | 1,064 km | 2h 10m | KA |
| Karachi | KHI | Pakistan | 1,104 km | 2h 0m | CA, PA, PK, PF, 9P |
| Urumqi | URC | China | 1,710 km | 2h 40m | CZ |
| Muscat | MCT | Oman | 1,796 km | 3h 15m | PK, PF, OV |
| Al-Fujairah | FJR | United Arab Emirates | 1,851 km | 3h 28m | PK |
| Ras al-Khaimah | RKT | United Arab Emirates | 1,853 km | 3h 25m | G9 |
| Sharjah | SHJ | United Arab Emirates | 1,906 km | 3h 35m | PA, PK, 9P |
| Dubai | DXB | United Arab Emirates | 1,923 km | 3h 30m | EK, PA, PK, FZ, PF |
| Al Ain | AAN | United Arab Emirates | 1,964 km | 3h 23m | PK |
| Tehran | IKA | Iran | 1,997 km | 3h 45m | B9, W5 |
| Abu Dhabi | AUH | United Arab Emirates | 2,035 km | 3h 25m | EY, PA, PK, PF |
| Baku | GYD | Azerbaijan | 2,159 km | 3h 35m | J2 |
| Doha | DOH | Qatar | 2,248 km | 3h 45m | QR, PK |
| Bahrain | BAH | Bahrain | 2,284 km | 3h 55m | GF, PK, 9P |
| Dammam | DMM | Saudi Arabia | 2,349 km | 4h 0m | PK, PF, 9P, PA |
| Kuwait | KWI | Kuwait | 2,405 km | 4h 0m | KU, J9 |
| Baghdad | BGW | Iraq | 2,651 km | 4h 20m | IA |
| Riyadh | RUH | Saudi Arabia | 2,702 km | 4h 15m | PA, PK, SV, XY, PF, 9P, F3 |
| Gassim | ELQ | Saudi Arabia | 2,907 km | 4h 35m | PK |
| Madinah | MED | Saudi Arabia | 3,360 km | 5h 5m | PK |
| Jeddah | JED | Saudi Arabia | 3,555 km | 5h 5m | PA, PK, SV, PF, 9P |
| Bangkok | BKK | Thailand | 3,578 km | 4h 45m | TG |
| Beijing | PEK | China | 3,931 km | 5h 35m | PK, CA |
| Istanbul | IST | Turkiye | 3,951 km | 6h 10m | TK |
| Guangzhou | CAN | China | 4,092 km | 5h 45m | CZ |
| Kuala Lumpur | KUL | Malaysia | 4,544 km | 8h 45m | PK |
| Paris | CDG | France | 5,906 km | 8h 15m | PK |
| London | LGW | United Kingdom | 6,053 km | 8h 55m | BA |
| London | LHR | United Kingdom | 6,065 km | 8h 0m | PK |
| Manchester | MAN | United Kingdom | 6,146 km | 8h 30m | PK |
| Toronto | YYZ | Canada | 11,007 km | 14h 25m | PK |