Multan International offers nonstop service to 27 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Sukkur | SKZ | Pakistan | 374 km | 1h 25m | SQB |
| Islamabad | ISB | Pakistan | 394 km | 2h 0m | SQB |
| Quetta | UET | Pakistan | 429 km | 1h 25m | SQB |
| Karachi | KHI | Pakistan | 721 km | 1h 25m | 9P, PK |
| Muscat | MCT | Oman | 1,493 km | 2h 45m | OV, PK |
| Sharjah | SHJ | United Arab Emirates | 1,655 km | 2h 55m | G9, PA, PK |
| Dubai | DXB | United Arab Emirates | 1,672 km | 3h 5m | FZ, PA, PK |
| Abu Dhabi | AUH | United Arab Emirates | 1,776 km | 3h 0m | 3L |
| Doha | DOH | Qatar | 2,024 km | 3h 35m | QR |
| Dammam | DMM | Saudi Arabia | 2,156 km | 4h 5m | PK |
| Riyadh | RUH | Saudi Arabia | 2,502 km | 4h 58m | PK |
| Gassim | ELQ | Saudi Arabia | 2,740 km | 4h 50m | PK |
| Madinah | MED | Saudi Arabia | 3,188 km | 5h 0m | PF, PK |
| Jeddah | JED | Saudi Arabia | 3,354 km | 5h 20m | PA, PF, PK, SV |