Jinnah International offers nonstop service to 69 destinations, served by 26 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Sukkur | SKZ | Pakistan | 352 km | 1h 10m | PK |
| Turbat | TUK | Pakistan | 429 km | 1h 25m | PK |
| Gwadar | GWD | Pakistan | 488 km | 1h 30m | PK |
| Quetta | UET | Pakistan | 593 km | 1h 20m | 9P, PF, PK |
| Multan | MUX | Pakistan | 721 km | 1h 25m | 9P, PK |
| Muscat | MCT | Oman | 913 km | 1h 50m | OV |
| Faisalabad | LYP | Pakistan | 916 km | 1h 40m | 9P, PK |
| Lahore | LHE | Pakistan | 1,020 km | 1h 45m | 9P, PA, PF, PK |
| Peshawar | PEW | Pakistan | 1,091 km | 1h 50m | 9P |
| Sialkot | SKT | Pakistan | 1,099 km | 1h 50m | 9P |
| Islamabad | ISB | Pakistan | 1,104 km | 1h 55m | 9P, PA, PF, PK |
| Sharjah | SHJ | United Arab Emirates | 1,175 km | 1h 55m | G9 |
| Dubai | DXB | United Arab Emirates | 1,190 km | 2h 15m | EK, FZ, PA |
| Abu Dhabi | AUH | United Arab Emirates | 1,268 km | 2h 10m | EY |
| Skardu | KDU | Pakistan | 1,408 km | 2h 15m | PK |
| Doha | DOH | Qatar | 1,568 km | 2h 30m | QR |
| Bahrain | BAH | Bahrain | 1,667 km | 3h 0m | GF |
| Dammam | DMM | Saudi Arabia | 1,751 km | 3h 15m | 9P, PK, XY |
| Tashkent | TAS | Uzbekistan | 1,824 km | 3h 10m | C6 |
| Kuwait | KWI | Kuwait | 1,961 km | 3h 53m | J9 |
| Riyadh | RUH | Saudi Arabia | 2,065 km | 3h 45m | 9P, F3, PK, SV, XY |
| Dhaka | DAC | Bangladesh | 2,357 km | 3h 39m | BG |
| Colombo | CMB | Sri Lanka | 2,383 km | 3h 35m | UL |
| Baghdad | BGW | Iraq | 2,410 km | 3h 50m | IA |
| Madinah | MED | Saudi Arabia | 2,774 km | 4h 20m | F3, PK, XY |
| Jeddah | JED | Saudi Arabia | 2,883 km | 4h 25m | 9P, F3, PA, PF, PK, SV, XY |
| Amman | AMM | Jordan | 3,138 km | 5h 35m | RJ |
| Addis Ababa | ADD | Ethiopia | 3,484 km | 5h 30m | ET |
| Bangkok | BKK | Thailand | 3,728 km | 4h 50m | TG |
| Istanbul | SAW | Turkiye | 3,920 km | 6h 20m | PC |
| Istanbul | IST | Turkiye | 3,976 km | 6h 5m | TK |
| Kuala Lumpur | KUL | Malaysia | 4,441 km | 6h 15m | OD |
| Beijing | PEK | China | 4,870 km | 6h 45m | CA |
| Toronto | YYZ | Canada | 11,690 km | 15h 0m | PK |