San Carlos offers nonstop service to 20 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Santiago | SCL | Chile | 860 km | 1h 50m | H2 |
| Mendoza | MDZ | Argentina | 946 km | 1h 41m | AR, JA |
| El Calafate | FTE | Argentina | 1,018 km | 1h 50m | AR |
| Cordoba | COR | Argentina | 1,255 km | 2h 5m | AR |
| Rosario | ROS | Argentina | 1,295 km | 2h 0m | AR |
| Buenos Aires | EZE | Argentina | 1,310 km | 2h 5m | AR, JA |
| Buenos Aires | AEP | Argentina | 1,336 km | 2h 5m | AR, JA |
| Montevideo | MVD | Uruguay | 1,499 km | 2h 20m | AR |
| Punta Del Este | PDP | Uruguay | 1,571 km | 2h 30m | AR |
| Sao Paulo | GRU | Brazil | 3,024 km | 4h 15m | LA |