Siem Reap-Ankor International Airport offers nonstop service to 15 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Phnom Penh | KTI | Cambodia | 234 km | 0h 50m | K6 |
| Pakse | PKZ | Lao People's Democratic Republic | 257 km | 0h 55m | QV |
| Sihanoukville | KOS | Cambodia | 314 km | 1h 10m | K6 |
| Phu Quoc | PQC | Viet Nam | 354 km | 1h 5m | KT |
| Bangkok | BKK | Thailand | 377 km | 1h 25m | PG, TG, EK |
| Ho Chi Minh City | SGN | Viet Nam | 387 km | 1h 15m | K6, VN |
| Bangkok | DMK | Thailand | 395 km | 1h 10m | FD |
| Da Nang | DAD | Viet Nam | 521 km | 1h 50m | K6 |
| Luang Prabang | LPQ | Lao People's Democratic Republic | 755 km | 1h 25m | VN |
| Phuket | HKT | Thailand | 870 km | 1h 35m | FD |
| Hanoi | HAN | Viet Nam | 884 km | 1h 45m | VJ, VN |
| Kuala Lumpur | KUL | Malaysia | 1,207 km | 2h 15m | KT, FY |
| Kunming | KMG | China | 1,305 km | 2h 20m | MU |
| Singapore | SIN | Singapore | 1,328 km | 2h 25m | SQ |
| Kolkata | CCU | India | 1,958 km | 3h 0m | 6E |