Manas International Airport offers nonstop service to 66 destinations, served by 24 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Almaty | ALA | Kazakhstan | 211 km | 0h 55m | KC |
| Osh | OSS | Kyrgyzstan | 305 km | 0h 55m | YK |
| Karakol | IKG | Kyrgyzstan | 326 km | 1h 0m | |
| Tashkent | TAS | Uzbekistan | 472 km | 1h 20m | C6, HH, HY |
| Dushanbe | DYU | Tajikistan | 690 km | 1h 20m | SZ |
| Astana | NQZ | Kazakhstan | 915 km | 2h 15m | IQ |
| Urumqi | URC | China | 1,055 km | 1h 55m | CZ |
| Novosibirsk | OVB | Russia | 1,456 km | 2h 25m | S7 |
| Delhi | DEL | India | 1,625 km | 3h 23m | KA |
| Yekaterinburg | SVX | Russia | 1,804 km | 3h 0m | U6 |
| Krasnojarsk | KJA | Russia | 1,944 km | 2h 43m | SU |
| Surgut | SGC | Russia | 2,035 km | 3h 13m | KA, UT |
| Baku | GYD | Azerbaijan | 2,043 km | 3h 20m | J2 |
| Makhachkala | MCX | Russia | 2,179 km | 3h 30m | WZ |
| Kazan | KZN | Russia | 2,279 km | 3h 40m | N4, YK |
| Sharjah | SHJ | United Arab Emirates | 2,617 km | 4h 5m | G9 |
| Dubai | DXB | United Arab Emirates | 2,632 km | 4h 35m | FZ |
| Moscow | DME | Russia | 2,950 km | 4h 20m | U6, YK |
| Moscow | VKO | Russia | 2,992 km | 4h 50m | KA |
| Moscow | SVO | Russia | 2,993 km | 4h 55m | SU |
| Chengdu | TFU | China | 3,006 km | 4h 30m | GJ |
| Xian | XIY | China | 3,105 km | 4h 25m | GJ |
| Ankara | ESB | Turkiye | 3,438 km | 5h 40m | VF |
| Beijing | PEK | China | 3,491 km | 4h 50m | CA |
| Beijing | PKX | China | 3,498 km | 4h 55m | CZ |
| Saint Petersburg | LED | Russia | 3,500 km | 5h 20m | U6, YK |
| Istanbul | SAW | Turkiye | 3,705 km | 5h 55m | PC, VF |
| Istanbul | IST | Turkiye | 3,737 km | 6h 0m | TK |
| Antalya | AYT | Turkiye | 3,748 km | 5h 50m | PC |
| Guangzhou | CAN | China | 4,172 km | 6h 15m | CZ |
| Seoul | ICN | Republic of Korea | 4,393 km | 6h 5m | TW |
| Nha Trang | CXR | Viet Nam | 4,796 km | 6h 30m | HH |