Nosy Be Fascene offers nonstop service to 21 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Dzaoudzi | DZA | Mayotte | 333 km | 1h 0m | ZD |
| Antananarivo | TNR | Madagascar | 613 km | 1h 40m | MD |
| Saint Denis de la Reunion | RUN | Reunion | 1,135 km | 1h 45m | UU |
| Zanzibar | ZNZ | United Republic of Tanzania | 1,268 km | 1h 45m | NO |
| Mombasa | MBA | Kenya | 1,403 km | 2h 10m | NO |
| Johannesburg | JNB | South Africa | 2,532 km | 3h 50m | 4Z |
| Addis Ababa | ADD | Ethiopia | 2,680 km | 4h 0m | ET |
| Rome | FCO | Italy | 7,134 km | 9h 0m | NO |
| Verona | VRN | Italy | 7,512 km | 9h 0m | NO |
| Milan | MXP | Italy | 7,643 km | 10h 25m | NO |
| Wroclaw | WRO | Poland | 7,759 km | 9h 50m | NO |
| Poznan | POZ | Poland | 7,884 km | 9h 55m | NO |