Dushanbe offers nonstop service to 32 destinations, served by 16 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tashkent | TAS | Uzbekistan | 303 km | 1h 0m | HY, SZ, C6 |
| Bishkek | BSZ | Kyrgyzstan | 690 km | 1h 30m | SZ, YK |
| Mashad | MHD | Iran | 851 km | 2h 0m | |
| Almaty | ALA | Kazakhstan | 873 km | 1h 45m | KC, SZ, DW |
| Delhi | DEL | India | 1,347 km | 3h 5m | SZ, DW |
| Astana | NQZ | Kazakhstan | 1,402 km | 2h 23m | SZ |
| Tehran | IKA | Iran | 1,608 km | 2h 43m | SZ, DW |
| Baku | GYD | Azerbaijan | 1,624 km | 2h 50m | J2 |
| Urumqi | URC | China | 1,668 km | 2h 45m | CZ, SZ, DW |
| Sharjah | SHJ | United Arab Emirates | 1,927 km | 2h 30m | DW |
| Chelyabinsk | CEK | Russia | 1,940 km | 3h 15m | U6 |
| Dubai | DXB | United Arab Emirates | 1,942 km | 3h 40m | FZ, SZ, DW |
| Ufa | UFA | Russia | 2,030 km | 3h 23m | U6, N4 |
| Tyumen | TJM | Russia | 2,087 km | 3h 20m | N4 |
| Novosibirsk | OVB | Russia | 2,104 km | 3h 10m | S7, SZ, DW |
| Yekaterinburg | SVX | Russia | 2,107 km | 3h 15m | SZ, U6, DW |
| Kuwait | KWI | Kuwait | 2,179 km | 3h 45m | J9 |
| Samara | KUF | Russia | 2,189 km | 3h 35m | U6, SZ |
| Mineralnye Vody | MRV | Russia | 2,231 km | 3h 40m | U6 |
| Kazan | KZN | Russia | 2,389 km | 3h 50m | SZ, U6, N4 |
| Adler/Sochi | AER | Russia | 2,476 km | 4h 5m | U6 |
| Trabzon | TZX | Turkiye | 2,490 km | 3h 50m | SZ |
| Krasnodar | KRR | Russia | 2,553 km | 4h 5m | U6 |
| Krasnojarsk | KJA | Russia | 2,626 km | 3h 45m | SZ, U6 |
| Zhukovsky | ZIA | Russia | 2,958 km | 4h 40m | U6, SZ |
| Moscow | DME | Russia | 2,966 km | 4h 40m | SZ, U6, DW |
| Moscow | VKO | Russia | 3,009 km | 4h 40m | UT |
| Jeddah | JED | Saudi Arabia | 3,392 km | 5h 40m | SZ |
| Istanbul | IST | Turkiye | 3,409 km | 5h 30m | SZ, TK, DW |
| Xian | XIY | China | 3,579 km | 4h 10m | GJ |
| Saint Petersburg | LED | Russia | 3,585 km | 5h 30m | SZ, U6, DW |
| Beijing | PKX | China | 4,073 km | 5h 30m | CZ |