Mashhad offers nonstop service to 41 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Birjand | XBJ | Iran | 371 km | 1h 10m | IR |
| Sary | SRY | Iran | 579 km | 1h 15m | EP |
| Zabol | ACZ | Iran | 597 km | 1h 5m | QB |
| Yazd | AZD | Iran | 689 km | 1h 30m | EP |
| Now Shahr | NSH | Iran | 731 km | 1h 35m | EP |
| Tehran | THR | Iran | 752 km | 1h 20m | B9, EP, IR, QB |
| Zahedan | ZAH | Iran | 758 km | 1h 30m | EP, IR, QB |
| Kandahar | KDH | Afghanistan | 777 km | 1h 15m | |
| Ramsar | RZR | Iran | 805 km | 1h 35m | EP |
| Isfahan | IFN | Iran | 811 km | 1h 30m | B9, QB |
| Dushanbe | DYU | Tajikistan | 851 km | 1h 30m | |
| Kabul | KBL | Afghanistan | 888 km | 1h 45m | B9 |
| Rasht | RAS | Iran | 902 km | 1h 45m | B9, IS |
| Shiraz | SYZ | Iran | 992 km | 1h 45m | EP, QB, B9 |
| Zanjan | JWN | Iran | 1,010 km | 1h 40m | |
| Hamadan | HDM | Iran | 1,017 km | 1h 50m | |
| Bandar Abbas | BND | Iran | 1,047 km | 1h 50m | IS |
| Qeshm Island | GSM | Iran | 1,108 km | 2h 0m | QB |
| Ahwaz | AWZ | Iran | 1,144 km | 2h 0m | EP, B9, QB, IS |
| Kermanshah | KSH | Iran | 1,154 km | 2h 0m | QB, B9, IS |
| Bushehr | BUZ | Iran | 1,154 km | 2h 0m | B9 |
| Bandar Mahshahr | MRX | Iran | 1,160 km | 1h 55m | QB |
| Ala'Marvdasht | PGU | Iran | 1,178 km | 2h 0m | |
| Chah Bahar | ZBR | Iran | 1,198 km | 2h 13m | EP |
| Kish Island | KIH | Iran | 1,202 km | 2h 0m | IS |
| Tabriz | TBZ | Iran | 1,206 km | 2h 0m | B9, IS |
| Ilaam | IIL | Iran | 1,244 km | 2h 15m | EP |
| Abadan | ABD | Iran | 1,245 km | 2h 15m | EP, QB, B9, IS |
| Sharjah | SHJ | United Arab Emirates | 1,272 km | 2h 10m | G9 |
| Dubai | DXB | United Arab Emirates | 1,283 km | 2h 30m | FZ, B9, IS |
| Nazluy-ye Jonubi | OMH | Iran | 1,306 km | 2h 0m | B9 |
| Kuwait | KWI | Kuwait | 1,339 km | 2h 30m | IR, J9, KU, IS |
| Muscat | MCT | Oman | 1,406 km | 2h 10m | IS |
| Dammam | DMM | Saudi Arabia | 1,429 km | 2h 55m | IR |
| Doha | DOH | Qatar | 1,437 km | 2h 35m | QR |
| Baghdad | BGW | Iraq | 1,447 km | 3h 5m | IS, B9 |
| Karachi | KHI | Pakistan | 1,448 km | 2h 20m | IR |
| Lahore | LHE | Pakistan | 1,460 km | 3h 0m | W5, B9 |
| Al-Najaf | NJF | Iraq | 1,480 km | 3h 10m | QB, IS |
| Istanbul | SAW | Turkiye | 2,679 km | 4h 25m | PC |
| Istanbul | IST | Turkiye | 2,728 km | 4h 30m | TK, B9 |