Mashhad offers nonstop service to 69 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Zabol | ACZ | Iran | 597 km | 1h 30m | W5 |
| Kerman | KER | Iran | 708 km | 1h 35m | W5 |
| Now Shahr | NSH | Iran | 731 km | 2h 10m | IR |
| Tehran | THR | Iran | 752 km | 1h 20m | B9, IS, W5 |
| Zahedan | ZAH | Iran | 758 km | 1h 45m | W5 |
| Kandahar | KDH | Afghanistan | 777 km | 1h 15m | |
| Ramsar | RZR | Iran | 805 km | 2h 15m | IR |
| Isfahan | IFN | Iran | 811 km | 1h 30m | B9 |
| Dushanbe | DYU | Tajikistan | 851 km | 1h 30m | |
| Kabul | KBL | Afghanistan | 888 km | 1h 45m | B9 |
| Rasht | RAS | Iran | 902 km | 1h 45m | B9, IR, IS, QB |
| Arak | AJK | Iran | 921 km | 2h 30m | IR |
| Shiraz | SYZ | Iran | 992 km | 1h 38m | B9 |
| Zanjan | JWN | Iran | 1,010 km | 2h 10m | W5 |
| Ardabil | ADU | Iran | 1,020 km | 2h 15m | W5 |
| Bandar Abbas | BND | Iran | 1,047 km | 2h 0m | IR, IS |
| Ahwaz | AWZ | Iran | 1,144 km | 2h 0m | B9, IR, IS |
| Bushehr | BUZ | Iran | 1,154 km | 2h 0m | B9 |
| Kermanshah | KSH | Iran | 1,154 km | 2h 0m | B9, IR, IS |
| Ala'Marvdasht | PGU | Iran | 1,178 km | 2h 0m | |
| Chah Bahar | ZBR | Iran | 1,198 km | 2h 15m | W5 |
| Kish Island | KIH | Iran | 1,202 km | 2h 10m | IS |
| Tabriz | TBZ | Iran | 1,206 km | 2h 0m | B9, IS |
| Abadan | ABD | Iran | 1,245 km | 2h 15m | B9, IS, W5 |
| Dubai | DXB | United Arab Emirates | 1,283 km | 2h 30m | B9, IS |
| Nazluy-ye Jonubi | OMH | Iran | 1,306 km | 2h 0m | B9 |
| Kuwait | KWI | Kuwait | 1,339 km | 2h 50m | KU |
| Muscat | MCT | Oman | 1,406 km | 2h 40m | IS |
| Doha | DOH | Qatar | 1,437 km | 2h 45m | QR |
| Baghdad | BGW | Iraq | 1,447 km | 2h 35m | B9, IS |
| Lahore | LHE | Pakistan | 1,460 km | 3h 0m | B9 |
| Al-Najaf | NJF | Iraq | 1,480 km | 2h 40m | IR, IS |
| Istanbul | IST | Turkiye | 2,728 km | 4h 30m | B9, IR, TK |
| Sparta | SAR | USA | 11,189 km | 10h 40m | W5 |