Dunhuang Airport offers nonstop service to 19 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Jiayuguan | JGN | China | 314 km | 0h 48m | G5 |
| Hami | HMI | China | 319 km | 0h 55m | G5 |
| Huatugou | HTT | China | 396 km | 1h 8m | MU |
| Zhangye | YZY | China | 538 km | 1h 15m | G5 |
| Jinchang | JIC | China | 685 km | 1h 23m | G5 |
| Urumqi | URC | China | 724 km | 1h 55m | GS |
| Xining | XNN | China | 761 km | 1h 23m | 3U |
| Lanzhou | LHW | China | 881 km | 1h 30m | 3U, G5, MU, 9C, CA |
| Qingyang | IQN | China | 1,233 km | 2h 5m | G5 |
| Xian | XIY | China | 1,399 km | 2h 25m | MU |
| Chengdu | TFU | China | 1,409 km | 2h 25m | 3U |
| Chongqing | CKG | China | 1,592 km | 2h 50m | GS |
| Beijing | PKX | China | 1,856 km | 3h 3m | CA |
| Beijing | PEK | China | 1,861 km | 2h 55m | CA |
| Guangzhou | CAN | China | 2,554 km | 4h 35m | HU |
| Hangzhou | HGH | China | 2,579 km | 4h 0m | CA |
| Shanghai | PVG | China | 2,639 km | 3h 50m | MU |
| Hong Kong | HKG | Hong Kong SAR | 2,688 km | 4h 55m | HB |
| Kuala Lumpur | KUL | Malaysia | 4,208 km | 7h 5m | OD |