Dunhuang Airport offers nonstop service to 44 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Jiayuguan | JGN | China | 314 km | 0h 50m | G5 |
| Hami | HMI | China | 319 km | 0h 55m | G5 |
| Huatugou | HTT | China | 396 km | 1h 8m | MU |
| Zhangye | YZY | China | 538 km | 1h 20m | G5 |
| Turpan | TLQ | China | 562 km | 1h 20m | EU |
| Jinchang | JIC | China | 685 km | 1h 25m | G5 |
| Urumqi | URC | China | 724 km | 1h 35m | GS |
| Xining | XNN | China | 761 km | 1h 25m | 3U |
| Lanzhou | LHW | China | 881 km | 1h 35m | 3U, CA, G5, MU |
| Qingyang | IQN | China | 1,233 km | 2h 5m | G5 |
| Chengdu | CTU | China | 1,357 km | 2h 40m | EU |
| Xian | XIY | China | 1,399 km | 2h 25m | 9H, FU, MU |
| Chengdu | TFU | China | 1,409 km | 2h 25m | 3U |
| Chongqing | CKG | China | 1,592 km | 2h 55m | GS |
| Beijing | PKX | China | 1,856 km | 3h 0m | CA |
| Beijing | PEK | China | 1,861 km | 3h 5m | CA |
| Guangzhou | CAN | China | 2,554 km | 4h 40m | HU |
| Hangzhou | HGH | China | 2,579 km | 4h 0m | CA |
| Shanghai | PVG | China | 2,639 km | 3h 50m | HO, MU |
| Shenzhen | SZX | China | 2,652 km | 4h 28m | DZ, Y8 |
| Hong Kong | HKG | Hong Kong SAR | 2,688 km | 5h 15m | HB |
| Kuala Lumpur | KUL | Malaysia | 4,208 km | 7h 5m | OD |