Jiayuguan Airport offers nonstop service to 28 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Dunhuang | DNH | China | 314 km | 0h 55m | G5 |
| Jinchang | JIC | China | 375 km | 1h 10m | G5 |
| Lanzhou | LHW | China | 592 km | 1h 25m | DR, G5, MU |
| Yinchuan | INC | China | 716 km | 1h 45m | MU |
| Urumqi | URC | China | 1,006 km | 2h 3m | AQ |
| Xian | XIY | China | 1,102 km | 2h 0m | MU |
| Chengdu | TFU | China | 1,195 km | 2h 15m | 3U, GX |
| Chongqing | CKG | China | 1,355 km | 2h 28m | G5 |
| Zhengzhou | CGO | China | 1,495 km | 2h 45m | RY |
| Beijing | PKX | China | 1,547 km | 2h 45m | MF, MU |
| Changsha | CSX | China | 1,882 km | 3h 10m | AQ, MF |
| Shenyang | SHE | China | 2,125 km | 3h 40m | 9C |
| Guangzhou | CAN | China | 2,305 km | 4h 0m | AQ |
| Shanghai | PVG | China | 2,328 km | 3h 35m | HO, MU |