Jiayuguan Airport offers nonstop service to 15 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Dunhuang | DNH | China | 314 km | 0h 50m | G5 |
| Jinchang | JIC | China | 375 km | 1h 10m | G5 |
| Lanzhou | LHW | China | 592 km | 1h 20m | G5, MU, DR |
| Yinchuan | INC | China | 716 km | 1h 45m | MU |
| Urumqi | URC | China | 1,006 km | 2h 0m | AQ |
| Korla | KRL | China | 1,047 km | 2h 10m | G5 |
| Xian | XIY | China | 1,102 km | 2h 15m | MU |
| Chengdu | TFU | China | 1,195 km | 2h 15m | 3U, GX |
| Chongqing | CKG | China | 1,355 km | 2h 40m | G5 |
| Zhengzhou | CGO | China | 1,495 km | 2h 45m | RY |
| Beijing | PKX | China | 1,547 km | 3h 3m | MF, MU |
| Wuhan | WUH | China | 1,756 km | 3h 15m | AQ |
| Changsha | CSX | China | 1,882 km | 3h 5m | MF |
| Guangzhou | CAN | China | 2,305 km | 3h 40m | AQ |
| Shanghai | PVG | China | 2,328 km | 3h 28m | MU |