Diosdado Macapagal International offers nonstop service to 24 destinations, served by 15 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| San Jose | SJI | Philippines | 317 km | 1h 30m | DG |
| Naga | WNP | Philippines | 342 km | 1h 20m | DG |
| Busuanga | USU | Philippines | 344 km | 1h 25m | DG, PR, 2R, T6 |
| Caticlan | MPH | Philippines | 391 km | 1h 10m | DG, Z2, 5J, 2R |
| Masbate | MBT | Philippines | 456 km | 1h 35m | DG |
| El Nido | ENI | Philippines | 457 km | 1h 35m | T6, DG |
| Iloilo | ILO | Philippines | 525 km | 1h 20m | 5J |
| Basco | BSO | Philippines | 602 km | 1h 30m | PR |
| Puerto Princesa | PPS | Philippines | 633 km | 1h 25m | 5J |
| Cebu City | CEB | Philippines | 655 km | 1h 30m | 5J, DG |
| Panglao | TAG | Philippines | 712 km | 2h 20m | 5J, DG |
| Del Carmin | IAO | Philippines | 836 km | 2h 30m | PR, 2R, DG |
| Davao | DVO | Philippines | 1,050 km | 2h 0m | 5J |
| Hong Kong | HKG | Hong Kong SAR | 1,052 km | 2h 10m | 5J, UO |
| Taipei | TPE | Taiwan | 1,096 km | 2h 5m | BR, JX |
| Hanoi | HAN | Viet Nam | 1,695 km | 3h 50m | 5J |
| Bangkok | BKK | Thailand | 2,140 km | 3h 30m | 5J |
| Busan | PUS | Republic of Korea | 2,368 km | 3h 38m | LJ |
| Singapore | SIN | Singapore | 2,376 km | 3h 35m | 5J, TR |
| Cheongju | CJJ | Republic of Korea | 2,483 km | 3h 55m | |
| Seoul | ICN | Republic of Korea | 2,535 km | 3h 55m | LJ, OZ, 7C |
| Tokyo | NRT | Japan | 3,016 km | 4h 5m | 5J |
| Dubai | DXB | United Arab Emirates | 6,840 km | 8h 50m | EK |
| Doha | DOH | Qatar | 7,217 km | 9h 40m | QR |